[17] Elise Mertens 3-6,3-6 Naomi Osaka [2] 2021-03-29 19:00
Stadium: Grandstand Round: 26 Ground: Hardcourt outdoor
Head to Head
| WTA New York | 2020/08/28 15:00 | Elise Mertens v Naomi Osaka | 2-6,6-7 |
| WTA Osaka | 2019/09/21 06:45 | Naomi Osaka v Elise Mertens | 6-4,6-1 |
| WTA Wuhan | 2017/09/25 06:00 | Elise Mertens v Naomi Osaka | 6-4,1-6,6-4 |
Home History
| WTA Miami | 2021/03/28 17:10 | Elise Mertens v Anett Kontaveit | 6-2,0-6,6-2 |
| WTA Miami | 2021/03/26 15:00 | Elise Mertens v Katie Boulter | 6-4,6-1 |
| WTA Dubai | 2021/03/12 13:00 | Garbine Muguruza v Elise Mertens | 6-4,7-6 |
| WTA Dubai | 2021/03/11 11:20 | Elise Mertens v Jessica Pegula | 5-7,7-5,6-0 |
| WTA Dubai | 2021/03/10 10:30 | Caroline Garcia v Elise Mertens | 4-6,2-6 |
| WTA Dubai | 2021/03/09 12:50 | Shelby Rogers v Elise Mertens | 3-6,3-6 |
| WTA Dubai | 2021/03/08 17:00 | Viktoriya Tomova v Elise Mertens | 6-4,2-6,4-6 |
| Australian Open Women | 2021/02/15 07:00 | Elise Mertens v Karolina Muchova | 6-7,5-7 |
Away History
| WTA Miami | 2021/03/26 17:00 | Ajla Tomljanovic v Naomi Osaka | 6-7,4-6 |
| Australian Open Women | 2021/02/20 08:30 | Jennifer Brady v Naomi Osaka | 4-6,3-6 |
| Australian Open Women | 2021/02/18 03:00 | Naomi Osaka v Serena Williams | 6-3,6-4 |
| Australian Open Women | 2021/02/16 01:30 | Su-Wei Hsieh v Naomi Osaka | 2-6,2-6 |
| Australian Open Women | 2021/02/14 00:00 | Garbine Muguruza v Naomi Osaka | 6-4,4-6,5-7 |
| Australian Open Women | 2021/02/12 04:05 | Ons Jabeur v Naomi Osaka | 3-6,2-6 |
| Australian Open Women | 2021/02/10 08:00 | Caroline Garcia v Naomi Osaka | 2-6,3-6 |
| Australian Open Women | 2021/02/08 00:00 | Anastasia Pavlyuchenkova v Naomi Osaka | 1-6,2-6 |