[7] Tottenham 2-1 Southampton [14] 2021-04-21 17:00
Stadium: Tottenham Hotspur Stadium Round: 29
Referee: David Coote Home Manager: Jose Mourinho Away Manager: Ralph Hasenhuttl
Head to Head
| England Premier League | 2020/09/20 11:00 | Southampton v Tottenham | W | 2-5 |
| England FA Cup | 2020/02/05 19:45 | Tottenham v Southampton | W | 3-2 |
| England FA Cup | 2020/01/25 15:00 | Southampton v Tottenham | D | 1-1 |
| England Premier League | 2020/01/01 15:00 | Southampton v Tottenham | L | 1-0 |
| England Premier League | 2019/09/28 14:00 | Tottenham v Southampton | W | 2-1 |
| England Premier League | 2019/03/09 15:00 | Southampton v Tottenham | L | 2-1 |
| England Premier League | 2018/12/05 20:00 | Tottenham v Southampton | W | 3-1 |
| England Premier League | 2018/01/21 16:00 | Southampton v Tottenham | D | 1-1 |
Home History
| England Premier League | 2021/04/16 19:00 | Everton v Tottenham | D | 2-2 |
| England Premier League | 2021/04/11 15:30 | Tottenham v Man Utd | L | 1-3 |
| England Premier League | 2021/04/04 13:05 | Newcastle v Tottenham | D | 2-2 |
| England Premier League | 2021/03/21 19:30 | Aston Villa v Tottenham | W | 0-2 |
| UEFA Europa League | 2021/03/18 17:55 | Dinamo Zagreb v Tottenham | L | 3-0 |
| England Premier League | 2021/03/14 16:30 | Arsenal v Tottenham | L | 2-1 |
| UEFA Europa League | 2021/03/11 20:00 | Tottenham v Dinamo Zagreb | W | 2-0 |
| England Premier League | 2021/03/07 19:15 | Tottenham v Crystal Palace | W | 4-1 |
Away History
| England FA Cup | 2021/04/18 17:30 | Leicester v Southampton | L | 1-0 |
| England Premier League | 2021/04/12 17:00 | West Brom v Southampton | L | 3-0 |
| England Premier League | 2021/04/04 11:00 | Southampton v Burnley | W | 3-2 |
| England FA Cup | 2021/03/20 12:15 | Bournemouth v Southampton | W | 0-3 |
| England Premier League | 2021/03/14 12:00 | Southampton v Brighton | L | 1-2 |
| England Premier League | 2021/03/10 18:00 | Man City v Southampton | L | 5-2 |
| England Premier League | 2021/03/06 15:00 | Sheff Utd v Southampton | W | 0-2 |
| England Premier League | 2021/03/01 20:00 | Everton v Southampton | L | 1-0 |