[5] Guairena FC 0-1 Cerro Porteno [4] 2021-04-25 21:45
Stadium: Estadio Parque del Guaira Round: 13
Referee: Juan Eduardo Lopez Home Manager: Troadio Daniel Duarte Away Manager: Francisco Arce
Head to Head
| Paraguay Division Profesional | 2021/02/21 21:30 | Cerro Porteno v Guairena FC | D | 2-2 |
| Paraguay Division Profesional | 2020/11/07 21:15 | Guairena FC v Cerro Porteno | D | 1-1 |
| Paraguay Division Profesional | 2020/08/26 21:00 | Guairena FC v Cerro Porteno | L | 1-2 |
| Paraguay Division Profesional | 2020/02/15 22:15 | Cerro Porteno v Guairena FC | D | 2-2 |
Home History
| Paraguay Division Profesional | 2021/04/16 22:00 | Guairena FC v Olimpia Asuncion | L | 1-2 |
| Paraguay Division Profesional | 2021/04/12 00:30 | Libertad Asuncion v Guairena FC | L | 2-1 |
| Copa Sudamericana | 2021/04/08 22:15 | River Plate Asuncion v Guairena FC | L | 4-2 |
| Paraguay Division Profesional | 2021/04/03 22:15 | Guairena FC v Sportivo Luqueno | W | 3-0 |
| Paraguay Division Profesional | 2021/03/22 21:15 | Guairena FC v Sol de America | D | 2-2 |
| Copa Sudamericana | 2021/03/18 22:15 | Guairena FC v River Plate Asuncion | L | 1-2 |
| Paraguay Division Profesional | 2021/03/14 20:45 | Guarani Asuncion v Guairena FC | W | 0-3 |
| Paraguay Division Profesional | 2021/03/09 21:30 | Guairena FC v 12 de Octubre | D | 0-0 |
Away History
| Copa Libertadores | 2021/04/22 02:00 | America de Cali v Cerro Porteno | W | 0-2 |
| Paraguay Division Profesional | 2021/04/18 21:45 | Cerro Porteno v Libertad Asuncion | L | 0-3 |
| Paraguay Division Profesional | 2021/04/11 22:15 | Sportivo Luqueno v Cerro Porteno | D | 3-3 |
| Paraguay Division Profesional | 2021/04/04 23:00 | Cerro Porteno v Sol de America | W | 1-0 |
| Paraguay Division Profesional | 2021/03/21 21:15 | Cerro Porteno v Guarani Asuncion | W | 2-1 |
| Paraguay Division Profesional | 2021/03/13 21:30 | 12 de Octubre v Cerro Porteno | W | 0-2 |
| Paraguay Division Profesional | 2021/03/09 23:45 | Cerro Porteno v River Plate Asuncion | W | 3-0 |
| Paraguay Division Profesional | 2021/03/06 21:15 | Nacional Asuncion v Cerro Porteno | L | 2-0 |