[5] Guairena FC 0-1 Cerro Porteno [4] 2021-04-25 21:45
Stadium: Estadio Parque del Guaira Round: 13
Referee: Juan Eduardo Lopez Home Manager: Troadio Daniel Duarte Away Manager: Francisco Arce
Head to Head
| Paraguay Division Profesional | 2021/02/21 21:30 | Cerro Porteno v Guairena FC | D | 2-2 |
| Paraguay Division Profesional | 2020/11/07 21:15 | Guairena FC v Cerro Porteno | D | 1-1 |
| Paraguay Division Profesional | 2020/08/26 21:00 | Guairena FC v Cerro Porteno | L | 1-2 |
| Paraguay Division Profesional | 2020/02/15 22:15 | Cerro Porteno v Guairena FC | D | 2-2 |