Santos 0-2 Barcelona Guayaquil 2021-04-20 22:15
Stadium: Urbano Caldeira Round: 1
Referee: Andres Matonte Home Manager: Ariel Holan Away Manager: Fabian Bustos
Head to Head
| Copa Libertadores Qualification | 2017/09/21 00:45 | Santos v Barcelona Guayaquil | L | 0-1 |
| Copa Libertadores Qualification | 2017/09/14 00:45 | Barcelona Guayaquil v Santos | D | 1-1 |
Home History
| Brazil Campeonato Paulista | 2021/04/18 23:00 | Santos v Inter de Limeira | W | 2-1 |
| Brazil Campeonato Paulista | 2021/04/16 23:00 | Ponte Preta v Santos | L | 3-0 |
| Copa Libertadores Qualification | 2021/04/14 00:30 | Santos v San Lorenzo | D | 2-2 |
| Brazil Campeonato Paulista | 2021/04/11 01:00 | Santos v Botafogo SP | D | 0-0 |
| Copa Libertadores Qualification | 2021/04/07 00:30 | San Lorenzo v Santos | W | 1-3 |
| Copa Libertadores Qualification | 2021/03/16 22:15 | CD Lara v Santos | D | 1-1 |
| Brazil Campeonato Paulista | 2021/03/13 22:00 | Santos v Ituano | W | 2-1 |
| Copa Libertadores Qualification | 2021/03/09 22:15 | Santos v CD Lara | W | 2-1 |
Away History
| Ecuador LigaPro Serie A | 2021/04/17 00:00 | Mushuc Runa v Barcelona Guayaquil | D | 2-2 |
| Ecuador LigaPro Serie A | 2021/04/12 22:00 | Barcelona Guayaquil v SD Aucas | W | 3-0 |
| Ecuador LigaPro Serie A | 2021/04/08 22:00 | Deportivo Cuenca v Barcelona Guayaquil | L | 1-0 |
| Ecuador LigaPro Serie A | 2021/04/03 22:00 | Barcelona Guayaquil v Independiente del Valle | D | 2-2 |
| Ecuador LigaPro Serie A | 2021/03/20 23:30 | LDU Quito v Barcelona Guayaquil | D | 2-2 |
| Ecuador LigaPro Serie A | 2021/03/14 23:00 | Barcelona Guayaquil v Orense | W | 2-0 |
| Ecuador LigaPro Serie A | 2021/03/07 23:00 | Guayaquil City v Barcelona Guayaquil | W | 0-3 |
| Ecuador LigaPro Serie A | 2021/02/28 23:00 | Barcelona Guayaquil v Tecnico Universitario | W | 3-0 |