Santos 0-2 Barcelona Guayaquil 2021-04-20 22:15
Stadium: Urbano Caldeira Round: 1
Referee: Andres Matonte Home Manager: Ariel Holan Away Manager: Fabian Bustos
Head to Head
| Copa Libertadores Qualification | 2017/09/21 00:45 | Santos v Barcelona Guayaquil | L | 0-1 |
| Copa Libertadores Qualification | 2017/09/14 00:45 | Barcelona Guayaquil v Santos | D | 1-1 |