[8] La Serena 0-0 Union Espanola [16] 2021-04-24 19:30
Stadium: La Portada Round: 5
Referee: Hector Jona Home Manager: Miguel Ponce Away Manager: Jorge Alberto Pellicer Barcelo
Head to Head
| Chile Primera Division | 2021/02/10 21:30 | Union Espanola v La Serena | D | 1-1 |
| Chile Primera Division | 2020/10/03 14:00 | La Serena v Union Espanola | L | 0-2 |
| World Club Friendlies | 2017/01/17 23:30 | La Serena v Union Espanola | L | 1-2 |
Home History
| Chile Primera Division | 2021/04/17 22:00 | O'Higgins v La Serena | D | 0-0 |
| Chile Primera Division | 2021/04/11 19:00 | La Serena v Universidad de Chile | D | 0-0 |
| Chile Primera Division | 2021/04/04 21:00 | La Serena v Curico Unido | W | 2-0 |
| Chile Primera Division | 2021/03/30 23:00 | Audax Italiano v La Serena | L | 2-1 |
| Chile Primera Division | 2021/02/14 21:00 | La Serena v Audax Italiano | L | 0-2 |
| Chile Primera Division | 2021/02/10 21:30 | Union Espanola v La Serena | D | 1-1 |
| Chile Primera Division | 2021/02/05 20:00 | La Serena v Universidad Catolica | L | 1-2 |
| Chile Primera Division | 2021/01/24 20:00 | La Serena v Curico Unido | W | 2-0 |
Away History
| Chile Primera Division | 2021/04/20 00:30 | Universidad de Chile v Union Espanola | L | 2-1 |
| Chile Primera Division | 2021/04/10 20:00 | Union Espanola v Melipilla | L | 0-2 |
| Chile Primera Division | 2021/04/02 22:00 | Union La Calera v Union Espanola | L | 1-0 |
| Chile Primera Division | 2021/03/28 00:00 | Union Espanola v Santiago Wanderers | W | 3-1 |
| Copa Libertadores Qualification | 2021/03/17 00:30 | Independiente del Valle v Union Espanola | L | 6-2 |
| Copa Libertadores Qualification | 2021/03/10 00:30 | Union Espanola v Independiente del Valle | W | 1-0 |
| Chile Primera Division | 2021/02/15 13:30 | Cobresal v Union Espanola | L | 4-1 |
| Chile Primera Division | 2021/02/10 21:30 | Union Espanola v La Serena | D | 1-1 |