[11] New York City FC 1-0 Chicago Fire [22] 2021-10-27 23:30
Stadium: Yankee Stadium
Referee: Fotis Bazakos Home Manager: Ronny Deila Away Manager: Raphael Wicky
Head to Head
| USA MLS | 2021/09/30 00:00 | Chicago Fire v New York City FC | L | 2-0 |
| USA MLS | 2021/08/05 00:00 | Chicago Fire v New York City FC | D | 0-0 |
| USA MLS | 2020/11/08 20:30 | Chicago Fire v New York City FC | W | 3-4 |
| USA MLS | 2020/08/29 23:30 | New York City FC v Chicago Fire | W | 3-1 |
| USA MLS | 2019/05/25 19:30 | Chicago Fire v New York City FC | D | 1-1 |
| USA MLS | 2019/04/24 23:00 | New York City FC v Chicago Fire | W | 1-0 |
| USA MLS | 2018/09/26 23:00 | New York City FC v Chicago Fire | W | 2-0 |
| USA MLS | 2018/07/01 00:00 | Chicago Fire v New York City FC | L | 3-2 |
Home History
| USA MLS | 2021/10/23 23:30 | New York City FC v DC United | W | 6-0 |
| USA MLS | 2021/10/20 23:30 | Atlanta United v New York City FC | D | 1-1 |
| USA MLS | 2021/10/17 17:00 | New York Red Bulls v New York City FC | L | 1-0 |
| USA MLS | 2021/10/03 16:00 | New York City FC v Nashville SC | D | 0-0 |
| USA MLS | 2021/09/30 00:00 | Chicago Fire v New York City FC | L | 2-0 |
| USA MLS | 2021/09/26 00:00 | New York City FC v New York Red Bulls | L | 0-1 |
| USA MLS | 2021/09/23 00:00 | New York Red Bulls v New York City FC | D | 1-1 |
| USA MLS | 2021/09/18 23:30 | FC Cincinnati v New York City FC | W | 1-2 |
Away History
| USA MLS | 2021/10/24 00:00 | Chicago Fire v Real Salt Lake | W | 1-0 |
| USA MLS | 2021/10/20 23:30 | FC Cincinnati v Chicago Fire | W | 3-4 |
| USA MLS | 2021/10/16 23:00 | New England Revolution v Chicago Fire | D | 2-2 |
| USA MLS | 2021/10/03 20:00 | Toronto FC v Chicago Fire | L | 3-1 |
| USA MLS | 2021/09/30 00:00 | Chicago Fire v New York City FC | W | 2-0 |
| USA MLS | 2021/09/26 17:00 | Chicago Fire v Nashville SC | D | 0-0 |
| USA MLS | 2021/09/23 00:00 | Chicago Fire v New England Revolution | L | 2-3 |
| USA MLS | 2021/09/19 17:00 | CF Montreal v Chicago Fire | L | 2-0 |