SO Illinois 26-31 South Dakota State 2021-05-03 01:00
Stadium: Dana J. Dykhouse Stadium Round: 1
Head to Head
| NCAAF | 2021/03/20 17:00 | South Dakota State v SO Illinois | L | 44-3 |
| NCAAF | 2019/10/05 19:00 | SO Illinois v South Dakota State | L | 10-28 |
| NCAAF FCS | 2018/11/10 19:00 | South Dakota State v SO Illinois | L | 57-38 |
| NCAAF | 2017/10/07 23:00 | South Dakota State v SO Illinois | L | 49-14 |
Home History
| NCAAF | 2021/04/24 20:00 | SO Illinois v Weber State | W | 34-31 |
| NCAAF | 2021/04/17 17:00 | SE Louisiana v SO Illinois | W | 48-55 |
| NCAAF | 2021/03/27 19:00 | SO Illinois v Missouri St | L | 27-30 |
| NCAAF | 2021/03/20 17:00 | South Dakota State v SO Illinois | L | 44-3 |
| NCAAF | 2021/03/13 18:00 | Northern Iowa v SO Illinois | W | 16-17 |
| NCAAF | 2021/03/06 17:00 | SO Illinois v Youngstown State | W | 30-22 |
| NCAAF | 2021/02/27 18:00 | North Dakota State v SO Illinois | W | 14-38 |
| NCAAF | 2021/02/20 18:00 | SO Illinois v North Dakota | L | 21-44 |
Away History
| NCAAF | 2021/04/24 19:00 | Holy Cross v South Dakota State | W | 3-31 |
| NCAAF | 2021/04/17 19:30 | South Dakota State v North Dakota State | W | 27-17 |
| NCAAF | 2021/03/20 17:00 | South Dakota State v SO Illinois | W | 44-3 |
| NCAAF | 2021/03/13 20:00 | Youngstown State v South Dakota State | W | 17-19 |
| NCAAF | 2021/03/06 20:00 | Western Illinois v South Dakota State | W | 10-45 |
| NCAAF | 2021/02/27 18:00 | South Dakota State v North Dakota | L | 17-28 |
| NCAAF | 2021/02/20 01:00 | South Dakota State v Northern Iowa | W | 24-20 |
| NCAAF | 2019/12/07 19:00 | Northern Iowa v South Dakota State | L | 13-10 |