[27] Western Michigan 14-47 Michigan [27] 2021-09-04 16:00
Stadium: Michigan Stadium Round: 1
Home Manager: Jim Harbaugh Away Manager: Tim Lester
Head to Head
| NCAAF | 2018/09/08 16:00 | Western Michigan v Michigan | L | 3-49 |
| NCAAF | 2011/09/03 12:00 | Michigan v Western Michigan | L | 34-10 |
| NCAAF | 2009/09/05 12:00 | Michigan v Western Michigan | L | 31-7 |
| NCAAF | 2002/09/07 12:00 | Michigan v Western Michigan | L | 35-12 |
| NCAAF | 2001/09/22 12:00 | Michigan v Western Michigan | L | 38-21 |
Home History
| NCAAF | 2020/12/12 17:00 | Western Michigan v Ball State | L | 27-30 |
| NCAAF | 2020/12/05 19:00 | Eastern Michigan v Western Michigan | L | 53-42 |
| NCAAF | 2020/11/28 17:00 | Northern Illinois v Western Michigan | W | 27-30 |
| NCAAF | 2020/11/19 00:00 | Western Michigan v Central Michigan | W | 52-44 |
| NCAAF | 2020/11/12 01:00 | Toledo v Western Michigan | W | 38-41 |
| NCAAF | 2020/11/04 23:00 | Western Michigan v Akron | W | 58-13 |
| NCAAF | 2019/12/30 17:30 | Western Michigan v Western Kentucky | L | 20-23 |
| NCAAF | 2019/11/27 00:00 | Western Michigan v Northern Illinois | L | 14-17 |
Away History
| NCAAF | 2020/11/28 17:00 | Penn State v Michigan | L | 27-17 |
| NCAAF | 2020/11/22 00:30 | Michigan v Rutgers | W | 48-42 |
| NCAAF | 2020/11/15 00:30 | Wisconsin v Michigan | L | 49-11 |
| NCAAF | 2020/11/07 17:00 | Michigan v Indiana | L | 21-38 |
| NCAAF | 2020/10/31 16:00 | Michigan State v Michigan | L | 27-24 |
| NCAAF | 2020/10/24 23:30 | Michigan v Minnesota | W | 49-24 |
| NCAAF | 2020/01/01 18:00 | Michigan v Alabama | L | 16-35 |
| NCAAF | 2019/11/30 17:00 | Ohio State v Michigan | L | 56-27 |