[27] Western Michigan 14-47 Michigan [27] 2021-09-04 16:00
Stadium: Michigan Stadium Round: 1
Home Manager: Jim Harbaugh Away Manager: Tim Lester
Head to Head
| NCAAF | 2018/09/08 16:00 | Western Michigan v Michigan | L | 3-49 |
| NCAAF | 2011/09/03 12:00 | Michigan v Western Michigan | L | 34-10 |
| NCAAF | 2009/09/05 12:00 | Michigan v Western Michigan | L | 31-7 |
| NCAAF | 2002/09/07 12:00 | Michigan v Western Michigan | L | 35-12 |
| NCAAF | 2001/09/22 12:00 | Michigan v Western Michigan | L | 38-21 |