[8] La Serena 1-2 Union La Calera [1] 2021-08-14 18:00
Stadium: La Portada Round: 16
Referee: Cesar Deischler Home Manager: Miguel Ponce Away Manager: Francisco Meneghini
Head to Head
| Chile Primera Division | 2021/01/15 20:00 | La Serena v Union La Calera | L | 0-3 |
| Chile Primera Division | 2020/02/14 21:30 | Union La Calera v La Serena | L | 2-1 |
| Chile Primera B | 2017/08/12 23:00 | La Serena v Union La Calera | L | 0-1 |
| Chile Primera B | 2017/03/25 22:00 | La Serena v Union La Calera | L | 0-1 |
| Chile Primera B | 2016/11/13 23:00 | Union La Calera v La Serena | W | 0-1 |
Home History
| Chile Primera Division | 2021/08/08 00:00 | Universidad Catolica v La Serena | L | 4-3 |
| Chile Primera Division | 2021/08/02 18:30 | La Serena v CD Antofagasta | D | 1-1 |
| Chile Primera Division | 2021/07/25 16:30 | Huachipato v La Serena | D | 0-0 |
| Chile Primera Division | 2021/07/20 19:00 | La Serena v Palestino | W | 4-3 |
| Chile Cup | 2021/07/05 00:00 | Colo Colo v La Serena | L | 4-0 |
| Chile Cup | 2021/07/01 19:30 | La Serena v Colo Colo | L | 1-3 |
| Chile Cup | 2021/06/27 19:00 | La Serena v AC Colina | W | 5-0 |
| Chile Cup | 2021/06/23 19:30 | AC Colina v La Serena | W | 1-2 |
Away History
| Chile Primera Division | 2021/08/09 00:00 | Union La Calera v Everton de Vina | W | 1-0 |
| Chile Primera Division | 2021/08/01 15:00 | Huachipato v Union La Calera | D | 0-0 |
| Chile Primera Division | 2021/07/29 00:30 | Union La Calera v Palestino | W | 2-1 |
| Chile Primera Division | 2021/07/24 21:30 | Melipilla v Union La Calera | D | 3-3 |
| Chile Primera Division | 2021/07/17 00:30 | Union La Calera v Curico Unido | W | 1-0 |
| Chile Cup | 2021/06/26 22:00 | Union La Calera v Deportes Temuco | L | 0-2 |
| Chile Cup | 2021/06/23 16:30 | Deportes Temuco v Union La Calera | D | 0-0 |
| Chile Primera Division | 2021/06/05 14:30 | Cobresal v Union La Calera | W | 0-1 |