[8] La Serena 1-2 Union La Calera [1] 2021-08-14 18:00
Stadium: La Portada Round: 16
Referee: Cesar Deischler Home Manager: Miguel Ponce Away Manager: Francisco Meneghini
Head to Head
| Chile Primera Division | 2021/01/15 20:00 | La Serena v Union La Calera | L | 0-3 |
| Chile Primera Division | 2020/02/14 21:30 | Union La Calera v La Serena | L | 2-1 |
| Chile Primera B | 2017/08/12 23:00 | La Serena v Union La Calera | L | 0-1 |
| Chile Primera B | 2017/03/25 22:00 | La Serena v Union La Calera | L | 0-1 |
| Chile Primera B | 2016/11/13 23:00 | Union La Calera v La Serena | W | 0-1 |