[30] HOU Texans 3-31 IND Colts [29] 2021-10-17 17:00
Stadium: Lucas Oil Stadium Round: 1
Home Manager: Frank Reich Away Manager: David Culley
Head to Head
| NFL | 2020/12/20 18:00 | HOU Texans v IND Colts | L | 20-27 |
| NFL | 2020/12/06 18:00 | IND Colts v HOU Texans | L | 26-20 |
| NFL | 2019/11/22 01:20 | IND Colts v HOU Texans | W | 17-20 |
| NFL | 2019/10/20 17:00 | HOU Texans v IND Colts | L | 23-30 |
| NFL | 2019/01/05 21:35 | IND Colts v HOU Texans | L | 21-7 |
| NFL | 2018/12/09 18:00 | IND Colts v HOU Texans | L | 24-21 |
| NFL | 2018/09/30 17:00 | HOU Texans v IND Colts | W | 37-34 |
| NFL | 2017/12/31 18:00 | HOU Texans v IND Colts | L | 13-22 |
Home History
| NFL | 2021/10/10 17:00 | NE Patriots v HOU Texans | L | 25-22 |
| NFL | 2021/10/03 17:00 | HOU Texans v BUF Bills | L | 0-40 |
| NFL | 2021/09/24 00:20 | CAR Panthers v HOU Texans | L | 24-9 |
| NFL | 2021/09/19 17:00 | HOU Texans v CLE Browns | L | 21-31 |
| NFL | 2021/09/12 17:00 | JAX Jaguars v HOU Texans | W | 21-37 |
| NFL Preseason | 2021/08/29 00:00 | TB Buccaneers v HOU Texans | L | 23-16 |
| NFL Preseason | 2021/08/22 00:00 | HOU Texans v DAL Cowboys | W | 20-14 |
| NFL Preseason | 2021/08/15 00:00 | HOU Texans v GB Packers | W | 26-7 |
Away History
| NFL | 2021/10/12 00:15 | IND Colts v BAL Ravens | L | 25-31 |
| NFL | 2021/10/03 17:00 | IND Colts v MIA Dolphins | W | 27-17 |
| NFL | 2021/09/26 17:00 | IND Colts v TEN Titans | L | 16-25 |
| NFL | 2021/09/19 17:00 | LA Rams v IND Colts | L | 27-24 |
| NFL | 2021/09/12 17:00 | SEA Seahawks v IND Colts | L | 28-16 |
| NFL Preseason | 2021/08/27 23:00 | IND Colts v DET Lions | W | 27-17 |
| NFL Preseason | 2021/08/22 00:00 | IND Colts v MIN Vikings | W | 12-10 |
| NFL Preseason | 2021/08/15 17:00 | CAR Panthers v IND Colts | W | 18-21 |