[30] HOU Texans 3-31 IND Colts [29] 2021-10-17 17:00
Stadium: Lucas Oil Stadium Round: 1
Home Manager: Frank Reich Away Manager: David Culley
Head to Head
| NFL | 2020/12/20 18:00 | HOU Texans v IND Colts | L | 20-27 |
| NFL | 2020/12/06 18:00 | IND Colts v HOU Texans | L | 26-20 |
| NFL | 2019/11/22 01:20 | IND Colts v HOU Texans | W | 17-20 |
| NFL | 2019/10/20 17:00 | HOU Texans v IND Colts | L | 23-30 |
| NFL | 2019/01/05 21:35 | IND Colts v HOU Texans | L | 21-7 |
| NFL | 2018/12/09 18:00 | IND Colts v HOU Texans | L | 24-21 |
| NFL | 2018/09/30 17:00 | HOU Texans v IND Colts | W | 37-34 |
| NFL | 2017/12/31 18:00 | HOU Texans v IND Colts | L | 13-22 |
| NFL | 2017/11/05 18:00 | IND Colts v HOU Texans | L | 20-14 |
| NFL | 2016/12/11 18:00 | HOU Texans v IND Colts | W | 22-17 |
| NFL | 2016/10/17 00:30 | IND Colts v HOU Texans | W | 23-26 |
| NFL | 2015/12/20 18:00 | IND Colts v HOU Texans | W | 10-16 |
| NFL | 2015/10/09 00:25 | HOU Texans v IND Colts | L | 20-27 |
| NFL | 2014/12/14 18:00 | IND Colts v HOU Texans | L | 17-10 |
| NFL | 2014/10/10 00:25 | HOU Texans v IND Colts | L | 28-33 |