[10] BUF Bills 6-9 JAX Jaguars [29] 2021-11-07 18:00
Stadium: EverBank Stadium Round: 1
Home Manager: Urban Meyer Away Manager: Sean McDermott
Head to Head
| NFL | 2018/11/25 18:00 | JAX Jaguars v BUF Bills | W | 21-24 |
| NFL | 2018/01/07 18:05 | BUF Bills v JAX Jaguars | L | 3-10 |
| NFL | 2016/11/27 18:00 | JAX Jaguars v BUF Bills | W | 21-28 |
| NFL | 2015/10/25 13:30 | JAX Jaguars v BUF Bills | L | 34-31 |
Home History
| NFL | 2021/10/31 17:00 | MIA Dolphins v BUF Bills | W | 11-26 |
| NFL | 2021/10/19 00:15 | BUF Bills v TEN Titans | L | 31-34 |
| NFL | 2021/10/11 00:20 | BUF Bills v KC Chiefs | W | 38-20 |
| NFL | 2021/10/03 17:00 | HOU Texans v BUF Bills | W | 0-40 |
| NFL | 2021/09/26 17:00 | WAS Commanders v BUF Bills | W | 21-43 |
| NFL | 2021/09/19 17:00 | BUF Bills v MIA Dolphins | W | 35-0 |
| NFL | 2021/09/12 17:00 | PIT Steelers v BUF Bills | L | 23-16 |
| NFL Preseason | 2021/08/28 17:00 | GB Packers v BUF Bills | W | 0-19 |
Away History
| NFL | 2021/10/31 20:05 | JAX Jaguars v SEA Seahawks | L | 7-31 |
| NFL | 2021/10/17 13:30 | MIA Dolphins v JAX Jaguars | W | 20-23 |
| NFL | 2021/10/10 17:00 | TEN Titans v JAX Jaguars | L | 37-19 |
| NFL | 2021/10/01 00:20 | JAX Jaguars v CIN Bengals | L | 21-24 |
| NFL | 2021/09/26 17:00 | ARZ Cardinals v JAX Jaguars | L | 31-19 |
| NFL | 2021/09/19 17:00 | DEN Broncos v JAX Jaguars | L | 23-13 |
| NFL | 2021/09/12 17:00 | JAX Jaguars v HOU Texans | L | 21-37 |
| NFL Preseason | 2021/08/29 17:00 | JAX Jaguars v DAL Cowboys | W | 34-14 |