[25] CAR Panthers 14-31 BUF Bills [12] 2021-12-19 18:00
Stadium: Bills Stadium Round: 1
Home Manager: Sean McDermott Away Manager: Matt Rhule
Head to Head
| NFL Preseason | 2019/08/16 23:00 | BUF Bills v CAR Panthers | L | 27-14 |
| NFL Preseason | 2018/08/09 23:00 | CAR Panthers v BUF Bills | W | 28-23 |
| NFL | 2018/02/02 09:34 | BUF Bills v CAR Panthers | W | 19-25 |
| NFL | 2017/09/17 17:00 | BUF Bills v CAR Panthers | W | 3-9 |
Home History
| NFL | 2021/12/12 18:00 | ATL Falcons v CAR Panthers | L | 29-21 |
| NFL | 2021/11/28 18:00 | CAR Panthers v MIA Dolphins | L | 10-33 |
| NFL | 2021/11/21 18:00 | WAS Commanders v CAR Panthers | L | 27-21 |
| NFL | 2021/11/14 21:05 | CAR Panthers v ARZ Cardinals | W | 34-10 |
| NFL | 2021/11/07 18:00 | NE Patriots v CAR Panthers | L | 24-6 |
| NFL | 2021/10/31 17:00 | CAR Panthers v ATL Falcons | W | 19-13 |
| NFL | 2021/10/24 17:00 | CAR Panthers v NY Giants | L | 3-25 |
| NFL | 2021/10/17 17:00 | MIN Vikings v CAR Panthers | L | 34-28 |
Away History
| NFL | 2021/12/12 21:25 | BUF Bills v TB Buccaneers | L | 27-33 |
| NFL | 2021/12/07 01:15 | NE Patriots v BUF Bills | L | 14-10 |
| NFL | 2021/11/26 01:20 | BUF Bills v NO Saints | W | 31-6 |
| NFL | 2021/11/21 18:00 | IND Colts v BUF Bills | L | 41-15 |
| NFL | 2021/11/14 18:00 | BUF Bills v NY Jets | W | 45-17 |
| NFL | 2021/11/07 18:00 | BUF Bills v JAX Jaguars | L | 6-9 |
| NFL | 2021/10/31 17:00 | MIA Dolphins v BUF Bills | W | 11-26 |
| NFL | 2021/10/19 00:15 | BUF Bills v TEN Titans | L | 31-34 |