[25] CAR Panthers 14-31 BUF Bills [12] 2021-12-19 18:00
Stadium: Bills Stadium Round: 1
Home Manager: Sean McDermott Away Manager: Matt Rhule
Head to Head
| NFL Preseason | 2019/08/16 23:00 | BUF Bills v CAR Panthers | L | 27-14 |
| NFL Preseason | 2018/08/09 23:00 | CAR Panthers v BUF Bills | W | 28-23 |
| NFL | 2018/02/02 09:34 | BUF Bills v CAR Panthers | W | 19-25 |
| NFL | 2017/09/17 17:00 | BUF Bills v CAR Panthers | W | 3-9 |