[29] HOU Texans 7-23 SF 49ers [15] 2022-01-02 21:05
Stadium: Levi's Stadium Round: 1
Home Manager: Kyle Shanahan Away Manager: David Culley
Head to Head
| NFL Preseason | 2018/08/19 00:00 | SF 49ers v HOU Texans | W | 13-16 |
| NFL | 2017/12/10 18:00 | SF 49ers v HOU Texans | L | 26-16 |
| NFL Preseason | 2016/08/14 23:00 | SF 49ers v HOU Texans | W | 13-24 |
Home History
| NFL | 2021/12/26 18:00 | LA Chargers v HOU Texans | W | 29-41 |
| NFL | 2021/12/19 18:00 | HOU Texans v JAX Jaguars | W | 30-16 |
| NFL | 2021/12/12 18:00 | SEA Seahawks v HOU Texans | L | 33-13 |
| NFL | 2021/12/05 18:00 | IND Colts v HOU Texans | L | 31-0 |
| NFL | 2021/11/28 18:00 | NY Jets v HOU Texans | L | 21-14 |
| NFL | 2021/11/21 18:00 | HOU Texans v TEN Titans | W | 22-13 |
| NFL | 2021/11/07 18:00 | HOU Texans v MIA Dolphins | L | 9-17 |
| NFL | 2021/10/31 17:00 | LA Rams v HOU Texans | L | 38-22 |
Away History
| NFL | 2021/12/24 01:20 | SF 49ers v TEN Titans | L | 17-20 |
| NFL | 2021/12/19 21:05 | ATL Falcons v SF 49ers | W | 13-31 |
| NFL | 2021/12/12 21:25 | SF 49ers v CIN Bengals | W | 26-23 |
| NFL | 2021/12/05 21:25 | SF 49ers v SEA Seahawks | L | 23-30 |
| NFL | 2021/11/28 21:25 | MIN Vikings v SF 49ers | W | 26-34 |
| NFL | 2021/11/21 18:00 | SF 49ers v JAX Jaguars | W | 30-10 |
| NFL | 2021/11/16 01:15 | LA Rams v SF 49ers | W | 10-31 |
| NFL | 2021/11/07 21:25 | ARZ Cardinals v SF 49ers | L | 31-17 |