[29] HOU Texans 7-23 SF 49ers [15] 2022-01-02 21:05
Stadium: Levi's Stadium Round: 1
Home Manager: Kyle Shanahan Away Manager: David Culley
Head to Head
| NFL Preseason | 2018/08/19 00:00 | SF 49ers v HOU Texans | W | 13-16 |
| NFL | 2017/12/10 18:00 | SF 49ers v HOU Texans | L | 26-16 |
| NFL Preseason | 2016/08/14 23:00 | SF 49ers v HOU Texans | W | 13-24 |