SF 49ers 15-10 LA Chargers 2021-08-22 23:30
Stadium: SoFi Stadium
Home Manager: Brandon Staley Away Manager: Kyle Shanahan
Head to Head
| NFL Preseason | 2019/08/30 02:00 | LA Chargers v SF 49ers | L | 27-24 |
| NFL | 2018/09/30 20:25 | SF 49ers v LA Chargers | L | 27-29 |
| NFL Preseason | 2018/08/31 02:00 | LA Chargers v SF 49ers | L | 23-21 |
| NFL Preseason | 2017/09/01 02:00 | LA Chargers v SF 49ers | W | 13-23 |
| NFL Preseason | 2016/09/02 02:00 | LA Chargers v SF 49ers | W | 21-31 |
| NFL | 2014/12/21 01:25 | SF 49ers v LA Chargers | L | 35-38 |
Home History
| NFL Preseason | 2021/08/15 00:30 | KC Chiefs v SF 49ers | L | 19-16 |
| NFL | 2021/01/03 21:25 | SEA Seahawks v SF 49ers | L | 26-23 |
| NFL | 2020/12/26 21:30 | SF 49ers v ARZ Cardinals | W | 20-12 |
| NFL | 2020/12/20 18:00 | SF 49ers v DAL Cowboys | L | 33-41 |
| NFL | 2020/12/13 21:25 | WAS Commanders v SF 49ers | L | 23-15 |
| NFL | 2020/12/08 01:15 | BUF Bills v SF 49ers | L | 34-24 |
| NFL | 2020/11/29 21:05 | SF 49ers v LA Rams | W | 23-20 |
| NFL | 2020/11/15 21:25 | SF 49ers v NO Saints | L | 13-27 |
Away History
| NFL Preseason | 2021/08/15 02:00 | LA Chargers v LA Rams | W | 13-6 |
| NFL | 2021/01/03 21:25 | LA Chargers v KC Chiefs | W | 38-21 |
| NFL | 2020/12/27 21:05 | DEN Broncos v LA Chargers | W | 16-19 |
| NFL | 2020/12/18 01:20 | LA Chargers v LV Raiders | W | 30-27 |
| NFL | 2020/12/13 21:25 | ATL Falcons v LA Chargers | W | 17-20 |
| NFL | 2020/12/06 21:25 | NE Patriots v LA Chargers | L | 45-0 |
| NFL | 2020/11/29 18:00 | LA Chargers v BUF Bills | L | 17-27 |
| NFL | 2020/11/22 21:05 | NY Jets v LA Chargers | W | 28-34 |