SF 49ers 15-10 LA Chargers 2021-08-22 23:30
Stadium: SoFi Stadium
Home Manager: Brandon Staley Away Manager: Kyle Shanahan
Head to Head
| NFL Preseason | 2019/08/30 02:00 | LA Chargers v SF 49ers | L | 27-24 |
| NFL | 2018/09/30 20:25 | SF 49ers v LA Chargers | L | 27-29 |
| NFL Preseason | 2018/08/31 02:00 | LA Chargers v SF 49ers | L | 23-21 |
| NFL Preseason | 2017/09/01 02:00 | LA Chargers v SF 49ers | W | 13-23 |
| NFL Preseason | 2016/09/02 02:00 | LA Chargers v SF 49ers | W | 21-31 |
| NFL | 2014/12/21 01:25 | SF 49ers v LA Chargers | L | 35-38 |