[6] Club Deportes Santa Cruz 2-2 Cobreloa [15] 2021-11-06 23:30
Stadium: Estadio Municipal Joaquín Muñoz García Round: 29
Head to Head
| Chile Primera B | 2021/08/08 15:00 | Cobreloa v Club Deportes Santa Cruz | W | 0-1 |
| Chile Primera B | 2020/12/10 13:00 | Club Deportes Santa Cruz v Cobreloa | W | 4-1 |
| Chile Primera B | 2020/09/06 15:00 | Cobreloa v Club Deportes Santa Cruz | W | 0-1 |
| Chile Primera B | 2019/06/02 19:00 | Club Deportes Santa Cruz v Cobreloa | W | 1-0 |
Home History
| Chile Primera B | 2021/11/01 21:00 | Club Deportes Santa Cruz v Barnechea | W | 2-0 |
| Chile Primera B | 2021/10/23 18:30 | Magallanes v Club Deportes Santa Cruz | D | 1-1 |
| Chile Primera B | 2021/10/19 19:00 | Club Deportes Santa Cruz v Rangers de Talca | W | 1-0 |
| Chile Primera B | 2021/10/12 21:00 | San Luis Quillota v Club Deportes Santa Cruz | D | 0-0 |
| Chile Primera B | 2021/10/08 21:30 | Club Deportes Santa Cruz v Deportes Copiapo | L | 1-2 |
| Chile Primera B | 2021/10/03 15:30 | Deportes Iquique v Club Deportes Santa Cruz | L | 6-1 |
| Chile Primera B | 2021/09/28 21:30 | Club Deportes Santa Cruz v Union San Felipe | L | 0-1 |
| Chile Primera B | 2021/09/24 00:00 | Coquimbo Unido v Club Deportes Santa Cruz | D | 0-0 |
Away History
| Chile Primera B | 2021/11/01 23:30 | Cobreloa v Deportes Temuco | L | 0-2 |
| Chile Primera B | 2021/10/27 23:00 | Puerto Montt v Cobreloa | D | 0-0 |
| Chile Primera B | 2021/10/20 22:00 | CD Arturo Fernández Vial v Cobreloa | L | 3-2 |
| Chile Primera B | 2021/10/16 18:00 | Cobreloa v Deportes Copiapo | W | 2-0 |
| Chile Primera B | 2021/10/12 23:30 | Deportes Iquique v Cobreloa | L | 1-0 |
| Chile Primera B | 2021/10/06 21:00 | Cobreloa v Magallanes | W | 2-1 |
| Chile Primera B | 2021/10/01 23:00 | San Luis Quillota v Cobreloa | L | 1-0 |
| Chile Primera B | 2021/09/26 17:00 | Cobreloa v CD Arturo Fernández Vial | L | 1-2 |