[6] Club Deportes Santa Cruz 2-2 Cobreloa [15] 2021-11-06 23:30
Stadium: Estadio Municipal Joaquín Muñoz García Round: 29
Head to Head
| Chile Primera B | 2021/08/08 15:00 | Cobreloa v Club Deportes Santa Cruz | W | 0-1 |
| Chile Primera B | 2020/12/10 13:00 | Club Deportes Santa Cruz v Cobreloa | W | 4-1 |
| Chile Primera B | 2020/09/06 15:00 | Cobreloa v Club Deportes Santa Cruz | W | 0-1 |
| Chile Primera B | 2019/06/02 19:00 | Club Deportes Santa Cruz v Cobreloa | W | 1-0 |