[4] Port Vale 3-2 Leyton Orient [2] 2021-10-02 14:00
Stadium: Vale Park Round: 10
Referee: Christopher Sarginson Home Manager: Darrell Clarke Away Manager: Kenneth Francis Jackett
Head to Head
| England League 2 | 2021/02/20 15:00 | Leyton Orient v Port Vale | D | 1-1 |
| England League 2 | 2020/11/28 13:00 | Port Vale v Leyton Orient | L | 2-3 |
| England League 2 | 2020/01/18 15:00 | Port Vale v Leyton Orient | W | 1-0 |
| England League 2 | 2019/09/28 14:00 | Leyton Orient v Port Vale | D | 3-3 |
| England League 1 | 2015/03/28 15:00 | Leyton Orient v Port Vale | L | 3-1 |
| England League 1 | 2014/10/25 14:00 | Port Vale v Leyton Orient | W | 3-0 |
Home History
| England League 2 | 2021/09/25 14:00 | Scunthorpe v Port Vale | W | 0-1 |
| England League 2 | 2021/09/18 14:00 | Port Vale v Harrogate Town | W | 2-0 |
| England League 2 | 2021/09/11 14:00 | Swindon v Port Vale | W | 1-2 |
| England League 2 | 2021/09/04 14:00 | Port Vale v Rochdale | L | 2-3 |
| England EFL Trophy | 2021/08/31 18:00 | Bolton v Port Vale | L | 3-2 |
| England League 2 | 2021/08/28 14:00 | Forest Green v Port Vale | W | 0-2 |
| England League 2 | 2021/08/21 14:00 | Stevenage v Port Vale | D | 1-1 |
| England League 2 | 2021/08/17 18:45 | Port Vale v Carlisle | D | 0-0 |
Away History
| England League 2 | 2021/09/25 14:00 | Leyton Orient v Mansfield | D | 0-0 |
| England League 2 | 2021/09/18 14:00 | Bristol Rovers v Leyton Orient | W | 1-3 |
| England EFL Trophy | 2021/09/14 18:00 | Leyton Orient v Southampton U21 | W | 1-0 |
| England League 2 | 2021/09/11 14:00 | Leyton Orient v Oldham | W | 4-0 |
| England League 2 | 2021/09/04 14:00 | Newport County v Leyton Orient | D | 2-2 |
| England League 2 | 2021/08/28 14:00 | Leyton Orient v Bradford | W | 2-0 |
| England League 2 | 2021/08/24 18:45 | Leyton Orient v Harrogate Town | L | 0-2 |
| England League 2 | 2021/08/21 14:00 | Carlisle v Leyton Orient | D | 1-1 |