[4] Port Vale 3-2 Leyton Orient [2] 2021-10-02 14:00
Stadium: Vale Park Round: 10
Referee: Christopher Sarginson Home Manager: Darrell Clarke Away Manager: Kenneth Francis Jackett
Head to Head
| England League 2 | 2021/02/20 15:00 | Leyton Orient v Port Vale | D | 1-1 |
| England League 2 | 2020/11/28 13:00 | Port Vale v Leyton Orient | L | 2-3 |
| England League 2 | 2020/01/18 15:00 | Port Vale v Leyton Orient | W | 1-0 |
| England League 2 | 2019/09/28 14:00 | Leyton Orient v Port Vale | D | 3-3 |
| England League 1 | 2015/03/28 15:00 | Leyton Orient v Port Vale | L | 3-1 |
| England League 1 | 2014/10/25 14:00 | Port Vale v Leyton Orient | W | 3-0 |