[23] River Plate 4-0 Union Santa Fe [16] 2021-07-25 21:00
Stadium: Estadio Monumental Antonio Vespucio Liberti Round: 2
Referee: Hernan Mastrangelo Home Manager: Marcelo Gallardo Away Manager: Juan Manuel Azconzabal
Head to Head
| Argentina Superliga | 2020/02/10 00:45 | Union Santa Fe v River Plate | W | 1-2 |
| Argentina Superliga | 2019/01/24 00:00 | River Plate v Union Santa Fe | L | 1-2 |
| Argentina Superliga | 2017/11/22 22:15 | River Plate v Union Santa Fe | W | 2-0 |
| Argentina Superliga | 2017/03/12 22:10 | River Plate v Union Santa Fe | D | 0-0 |
| Argentina Cup | 2016/10/28 00:10 | River Plate v Union Santa Fe | W | 3-0 |
| Argentina Liga Profesional | 2015/03/08 21:15 | River Plate v Union Santa Fe | D | 2-2 |
Home History
| Copa Libertadores Qualification | 2021/07/22 00:30 | Argentinos Jrs v River Plate | W | 0-2 |
| Argentina Liga Profesional | 2021/07/18 21:00 | River Plate v Colon | L | 1-2 |
| Copa Libertadores Qualification | 2021/07/15 00:30 | River Plate v Argentinos Jrs | D | 1-1 |
| Copa Libertadores | 2021/05/25 22:15 | River Plate v Fluminense | L | 1-3 |
| Copa Libertadores | 2021/05/20 00:00 | River Plate v Independiente Santa Fe | W | 2-1 |
| Argentina Copa de la Liga Profesional | 2021/05/16 20:30 | Boca Juniors v River Plate | L | 5-3 |
| Copa Libertadores | 2021/05/13 00:00 | Junior v River Plate | D | 1-1 |
| Argentina Copa de la Liga Profesional | 2021/05/09 17:30 | River Plate v CA Aldosivi | W | 4-1 |
Away History
| Argentina Liga Profesional | 2021/07/16 22:00 | Union Santa Fe v Boca Juniors | D | 1-1 |
| Argentina Copa de la Liga Profesional | 2021/05/09 21:00 | Colon v Union Santa Fe | D | 1-1 |
| Argentina Copa de la Liga Profesional | 2021/05/02 15:10 | Defensa y Justicia v Union Santa Fe | W | 0-1 |
| Argentina Copa de la Liga Profesional | 2021/04/25 00:00 | Union Santa Fe v CA Independiente | D | 0-0 |
| Argentina Copa de la Liga Profesional | 2021/04/16 18:00 | CA Talleres de Córdoba v Union Santa Fe | L | 3-0 |
| Argentina Copa de la Liga Profesional | 2021/04/11 21:30 | Union Santa Fe v Boca Juniors | W | 1-0 |
| Argentina Copa de la Liga Profesional | 2021/04/04 21:30 | Velez Sarsfield v Union Santa Fe | L | 4-1 |
| Argentina Copa de la Liga Profesional | 2021/03/27 00:15 | Union Santa Fe v Sarmiento | D | 0-0 |