[23] River Plate 4-0 Union Santa Fe [16] 2021-07-25 21:00
Stadium: Estadio Monumental Antonio Vespucio Liberti Round: 2
Referee: Hernan Mastrangelo Home Manager: Marcelo Gallardo Away Manager: Juan Manuel Azconzabal
Head to Head
| Argentina Superliga | 2020/02/10 00:45 | Union Santa Fe v River Plate | W | 1-2 |
| Argentina Superliga | 2019/01/24 00:00 | River Plate v Union Santa Fe | L | 1-2 |
| Argentina Superliga | 2017/11/22 22:15 | River Plate v Union Santa Fe | W | 2-0 |
| Argentina Superliga | 2017/03/12 22:10 | River Plate v Union Santa Fe | D | 0-0 |
| Argentina Cup | 2016/10/28 00:10 | River Plate v Union Santa Fe | W | 3-0 |
| Argentina Liga Profesional | 2015/03/08 21:15 | River Plate v Union Santa Fe | D | 2-2 |