[16] Rosario Central 1-0 San Lorenzo [18] 2021-09-20 21:00
Stadium: Estadio Dr. Lisandro de la Torre Round: 12
Referee: Fernando Echenique Home Manager: Kily Gonzalez Away Manager: Paolo Montero
Head to Head
| Copa Sudamericana | 2021/05/13 00:30 | San Lorenzo v Rosario Central | W | 1-2 |
| Copa Sudamericana | 2021/04/29 00:30 | Rosario Central v San Lorenzo | W | 2-0 |
| Argentina Copa de la Liga Profesional | 2021/04/02 22:00 | San Lorenzo v Rosario Central | L | 2-0 |
| Argentina Superliga | 2019/08/17 20:45 | San Lorenzo v Rosario Central | D | 2-2 |
| Argentina Superliga | 2019/03/17 18:30 | Rosario Central v San Lorenzo | L | 0-1 |
| Argentina Superliga | 2017/09/10 19:05 | Rosario Central v San Lorenzo | D | 0-0 |
| Argentina Superliga | 2017/05/07 21:15 | San Lorenzo v Rosario Central | L | 2-1 |
| Argentina Liga Profesional | 2016/04/17 18:30 | San Lorenzo v Rosario Central | L | 2-1 |
Home History
| Argentina Liga Profesional | 2021/09/15 21:45 | Banfield v Rosario Central | W | 1-2 |
| Argentina Liga Profesional | 2021/09/04 23:15 | Rosario Central v Boca Juniors | L | 1-2 |
| Argentina Liga Profesional | 2021/08/29 18:45 | Central Cordoba v Rosario Central | W | 2-4 |
| Argentina Liga Profesional | 2021/08/25 17:15 | Rosario Central v Arsenal de Sarandi | W | 4-0 |
| Argentina Liga Profesional | 2021/08/22 18:45 | Newell's v Rosario Central | D | 1-1 |
| Copa Sudamericana | 2021/08/17 22:15 | Bragantino v Rosario Central | L | 1-0 |
| Argentina Liga Profesional | 2021/08/14 23:15 | Rosario Central v CA Independiente | L | 1-2 |
| Copa Sudamericana | 2021/08/10 22:15 | Rosario Central v Bragantino | L | 3-4 |
Away History
| Argentina Liga Profesional | 2021/09/13 21:45 | San Lorenzo v Racing Club | D | 1-1 |
| Argentina Liga Profesional | 2021/09/04 21:00 | Platense v San Lorenzo | D | 1-1 |
| Argentina Liga Profesional | 2021/08/30 19:45 | San Lorenzo v Patronato Parana | W | 3-0 |
| Argentina Liga Profesional | 2021/08/26 21:45 | Estudiantes LP v San Lorenzo | L | 2-0 |
| Argentina Liga Profesional | 2021/08/22 21:00 | San Lorenzo v Argentinos Jrs | L | 0-1 |
| Argentina Liga Profesional | 2021/08/16 21:00 | CA Talleres de Córdoba v San Lorenzo | L | 2-0 |
| Argentina Liga Profesional | 2021/08/07 18:45 | Union Santa Fe v San Lorenzo | L | 4-0 |
| Argentina Liga Profesional | 2021/08/01 23:15 | San Lorenzo v Banfield | D | 1-1 |