[16] Rosario Central 1-0 San Lorenzo [18] 2021-09-20 21:00
Stadium: Estadio Dr. Lisandro de la Torre Round: 12
Referee: Fernando Echenique Home Manager: Kily Gonzalez Away Manager: Paolo Montero
Head to Head
| Copa Sudamericana | 2021/05/13 00:30 | San Lorenzo v Rosario Central | W | 1-2 |
| Copa Sudamericana | 2021/04/29 00:30 | Rosario Central v San Lorenzo | W | 2-0 |
| Argentina Copa de la Liga Profesional | 2021/04/02 22:00 | San Lorenzo v Rosario Central | L | 2-0 |
| Argentina Superliga | 2019/08/17 20:45 | San Lorenzo v Rosario Central | D | 2-2 |
| Argentina Superliga | 2019/03/17 18:30 | Rosario Central v San Lorenzo | L | 0-1 |
| Argentina Superliga | 2017/09/10 19:05 | Rosario Central v San Lorenzo | D | 0-0 |
| Argentina Superliga | 2017/05/07 21:15 | San Lorenzo v Rosario Central | L | 2-1 |
| Argentina Liga Profesional | 2016/04/17 18:30 | San Lorenzo v Rosario Central | L | 2-1 |
| Argentina Liga Profesional | 2015/10/03 21:10 | San Lorenzo v Rosario Central | D | 2-2 |
| Argentina Liga Profesional | 2014/09/07 18:00 | Rosario Central v San Lorenzo | D | 1-1 |