[4] Sevilla 1-0 Villarreal [12] 2021-12-04 13:00
Stadium: Ramon Sanchez Pizjuan Round: 16
Referee: Carlos Del Cerro Grande Home Manager: Julen Lopetegui Away Manager: Unai Emery
Head to Head
| Spain La Liga | 2021/05/16 16:30 | Villarreal v Sevilla | L | 4-0 |
| Spain La Liga | 2020/12/29 16:00 | Sevilla v Villarreal | W | 2-0 |
| Spain La Liga | 2020/06/22 17:30 | Villarreal v Sevilla | D | 2-2 |
| Spain La Liga | 2019/12/15 17:30 | Sevilla v Villarreal | L | 1-2 |
| Spain La Liga | 2019/02/17 17:30 | Villarreal v Sevilla | L | 3-0 |
| Spain La Liga | 2018/08/26 20:15 | Sevilla v Villarreal | D | 0-0 |
| Spain La Liga | 2018/04/14 11:00 | Sevilla v Villarreal | D | 2-2 |
| Spain La Liga | 2017/11/26 17:30 | Villarreal v Sevilla | W | 2-3 |
Home History
| Spain Copa del Rey | 2021/12/01 18:00 | Cordoba v Sevilla | W | 0-1 |
| Spain La Liga | 2021/11/28 20:00 | Real Madrid v Sevilla | L | 2-1 |
| UEFA Champions League | 2021/11/23 20:00 | Sevilla v Wolfsburg | W | 2-0 |
| Spain La Liga | 2021/11/20 15:15 | Sevilla v CD Alaves | D | 2-2 |
| Spain La Liga | 2021/11/07 20:00 | Real Betis v Sevilla | W | 0-2 |
| UEFA Champions League | 2021/11/02 20:00 | Sevilla v Lille | L | 1-2 |
| Spain La Liga | 2021/10/30 14:15 | Sevilla v Osasuna | W | 2-0 |
| Spain La Liga | 2021/10/27 17:00 | Mallorca v Sevilla | D | 1-1 |
Away History
| Spain Copa del Rey | 2021/11/30 18:00 | Victoria CF v Villarreal | W | 0-8 |
| Spain La Liga | 2021/11/27 20:00 | Villarreal v Barcelona | L | 1-3 |
| UEFA Champions League | 2021/11/23 17:45 | Villarreal v Man Utd | L | 0-2 |
| Spain La Liga | 2021/11/20 13:00 | Celta Vigo v Villarreal | D | 1-1 |
| Spain La Liga | 2021/11/07 13:00 | Villarreal v Getafe | W | 1-0 |
| UEFA Champions League | 2021/11/02 20:00 | Villarreal v Young Boys | W | 2-0 |
| Spain La Liga | 2021/10/30 16:30 | Valencia v Villarreal | L | 2-0 |
| Spain La Liga | 2021/10/26 19:30 | Villarreal v Cadiz | D | 3-3 |