Head to Head
| Mexico Liga MX | 2021/02/01 01:06 | Santos Laguna v Club America | D | 1-1 |
| Mexico Liga MX | 2020/08/14 02:00 | Club America v Santos Laguna | W | 3-1 |
| Mexico Liga MX | 2019/11/03 01:00 | Club America v Santos Laguna | L | 1-2 |
| Mexico Liga MX | 2019/04/28 00:00 | Club America v Santos Laguna | W | 1-0 |
| World Club Friendlies | 2018/12/29 22:30 | Club America v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2018/11/12 00:00 | Santos Laguna v Club America | D | 1-1 |
| Mexico Liga MX | 2018/05/14 00:00 | Club America v Santos Laguna | D | 2-2 |
| Mexico Liga MX | 2018/05/11 00:30 | Santos Laguna v Club America | L | 4-1 |
Home History
| Mexico Liga MX | 2021/05/17 01:05 | Club America v Pachuca | W | 4-2 |
| Mexico Liga MX | 2021/05/14 00:00 | Pachuca v Club America | L | 3-1 |
| CONCACAF Champions Cup | 2021/05/06 02:15 | Club America v Portland Timbers | W | 3-1 |
| Mexico Liga MX | 2021/05/03 02:05 | Unam Pumas v Club America | W | 0-1 |
| CONCACAF Champions Cup | 2021/04/29 02:30 | Portland Timbers v Club America | D | 1-1 |
| Mexico Liga MX | 2021/04/25 22:30 | Toluca v Club America | L | 3-1 |
| Mexico Liga MX | 2021/04/18 02:05 | Club America v Cruz Azul | D | 1-1 |
| CONCACAF Champions Cup | 2021/04/15 00:00 | Club America v CD Olimpia | L | 0-1 |
Away History
| Mexico Liga MX | 2021/05/31 01:15 | Cruz Azul v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2021/05/28 02:00 | Santos Laguna v Cruz Azul | L | 0-1 |
| Mexico Liga MX | 2021/05/24 00:00 | Puebla v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2021/05/21 02:00 | Santos Laguna v Puebla | W | 3-0 |
| Mexico Liga MX | 2021/05/16 23:00 | Monterrey v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2021/05/14 02:05 | Santos Laguna v Monterrey | W | 2-1 |
| Mexico Liga MX | 2021/05/09 02:15 | Santos Laguna v Queretaro | W | 5-0 |
| Mexico Liga MX | 2021/05/03 00:06 | Santos Laguna v Puebla | D | 0-0 |