[1] Club America 2-1 Santos Laguna [11] 2021-10-20 00:05
Stadium: Estadio Azteca Round: 14
Referee: Marco Antonio Ortiz Nava Home Manager: Santiago Hernan Solari Poggio Away Manager: Guillermo Almada
Head to Head
| Club Friendly List | 2021/07/05 00:30 | Club America v Santos Laguna | W | 1-0 |
| Mexico Liga MX | 2021/02/01 01:06 | Santos Laguna v Club America | D | 1-1 |
| Mexico Liga MX | 2020/08/14 02:00 | Club America v Santos Laguna | W | 3-1 |
| Mexico Liga MX | 2019/11/03 01:00 | Club America v Santos Laguna | L | 1-2 |
| Mexico Liga MX | 2019/04/28 00:00 | Club America v Santos Laguna | W | 1-0 |
| World Club Friendlies | 2018/12/29 22:30 | Club America v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2018/11/12 00:00 | Santos Laguna v Club America | D | 1-1 |
| Mexico Liga MX | 2018/05/14 00:00 | Club America v Santos Laguna | D | 2-2 |
Home History
| Mexico Liga MX | 2021/10/17 00:00 | Atletico San Luis v Club America | W | 0-1 |
| World Club Friendlies | 2021/10/09 01:30 | Club America v Unam Pumas | L | 0-1 |
| Mexico Liga MX | 2021/10/03 22:00 | Club America v Unam Pumas | W | 2-0 |
| Mexico Liga MX | 2021/09/29 02:05 | Pachuca v Club America | D | 1-1 |
| Mexico Liga MX | 2021/09/26 02:00 | Club America v Chivas Guadalajara | D | 0-0 |
| Mexico Liga MX | 2021/09/19 00:00 | Toluca v Club America | L | 3-1 |
| CONCACAF Champions Cup | 2021/09/16 01:00 | Philadelphia Union v Club America | W | 0-2 |
| Mexico Liga MX | 2021/09/12 02:00 | Club America v Mazatlan FC | W | 2-0 |
Away History
| Mexico Liga MX | 2021/10/17 00:00 | Pachuca v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2021/10/03 00:06 | Santos Laguna v Mazatlan FC | W | 1-0 |
| Mexico Liga MX | 2021/09/27 00:06 | Santos Laguna v Monterrey | L | 1-2 |
| Mexico Liga MX | 2021/09/20 02:06 | Santos Laguna v Puebla | D | 1-1 |
| Leagues Cup | 2021/09/15 02:00 | Seattle Sounders v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2021/09/11 02:06 | Tijuana v Santos Laguna | L | 2-1 |
| Mexico Liga MX | 2021/08/29 23:00 | Santos Laguna v Juarez FC | W | 2-0 |
| Mexico Liga MX | 2021/08/22 00:00 | Leon v Santos Laguna | D | 1-1 |