[14] Santos Laguna 2-2 Toluca [5] 2021-10-25 00:06
Stadium: Estadio TSM Corona Round: 15
Referee: Jorge Isaac Rojas Castillo Home Manager: Guillermo Almada Away Manager: Hernan Cristante
Head to Head
| Mexico Liga MX | 2021/04/19 00:00 | Santos Laguna v Toluca | W | 3-1 |
| Mexico Liga MX | 2020/09/20 17:00 | Toluca v Santos Laguna | W | 1-2 |
| Mexico Liga MX | 2019/11/24 18:00 | Toluca v Santos Laguna | D | 2-2 |
| Mexico Liga MX | 2019/02/25 00:06 | Santos Laguna v Toluca | W | 4-0 |
| Mexico Liga MX | 2018/09/02 17:00 | Toluca v Santos Laguna | L | 2-1 |
| Mexico Liga MX | 2018/05/21 00:00 | Toluca v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2018/05/18 01:00 | Santos Laguna v Toluca | W | 2-1 |
| Mexico Liga MX | 2018/02/18 18:00 | Toluca v Santos Laguna | L | 2-0 |
Home History
| Mexico Liga MX | 2021/10/20 00:05 | Club America v Santos Laguna | L | 2-1 |
| Mexico Liga MX | 2021/10/17 00:00 | Pachuca v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2021/10/03 00:06 | Santos Laguna v Mazatlan FC | W | 1-0 |
| Mexico Liga MX | 2021/09/27 00:06 | Santos Laguna v Monterrey | L | 1-2 |
| Mexico Liga MX | 2021/09/20 02:06 | Santos Laguna v Puebla | D | 1-1 |
| Leagues Cup | 2021/09/15 02:00 | Seattle Sounders v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2021/09/11 02:06 | Tijuana v Santos Laguna | L | 2-1 |
| Mexico Liga MX | 2021/08/29 23:00 | Santos Laguna v Juarez FC | W | 2-0 |
Away History
| Mexico Liga MX | 2021/10/21 00:00 | Toluca v Necaxa | D | 1-1 |
| Mexico Liga MX | 2021/10/17 22:00 | Chivas Guadalajara v Toluca | L | 2-0 |
| Mexico Liga MX | 2021/10/03 17:00 | Toluca v Queretaro | D | 1-1 |
| Mexico Liga MX | 2021/09/26 17:00 | Toluca v Atletico San Luis | L | 1-2 |
| Mexico Liga MX | 2021/09/23 00:06 | Monterrey v Toluca | L | 2-0 |
| Mexico Liga MX | 2021/09/19 00:00 | Toluca v Club America | W | 3-1 |
| Mexico Liga MX | 2021/09/14 02:00 | Pachuca v Toluca | W | 1-2 |
| Mexico Liga MX | 2021/08/29 17:00 | Toluca v Unam Pumas | W | 2-1 |