[17] Queretaro 2-3 Santos Laguna [12] 2021-10-30 22:00
Stadium: Estadio La Corregidora Round: 16
Referee: Jorge Antonio Perez Duran Home Manager: Leonardo Ramos Away Manager: Guillermo Almada
Head to Head
| Mexico Liga MX | 2021/05/09 02:15 | Santos Laguna v Queretaro | L | 5-0 |
| Mexico Liga MX | 2021/04/12 00:00 | Queretaro v Santos Laguna | W | 1-0 |
| Mexico Liga MX | 2020/08/31 00:06 | Santos Laguna v Queretaro | L | 2-1 |
| Mexico Liga MX | 2019/10/30 01:00 | Santos Laguna v Queretaro | L | 1-0 |
| Mexico Liga MX | 2019/04/21 23:06 | Santos Laguna v Queretaro | L | 2-1 |
| Mexico Liga MX | 2018/11/04 22:00 | Queretaro v Santos Laguna | W | 2-1 |
| Mexico Liga MX | 2018/04/08 23:00 | Santos Laguna v Queretaro | L | 3-0 |
| Mexico Cup | 2018/03/14 03:15 | Santos Laguna v Queretaro | L | 1-0 |
Home History
| Mexico Liga MX | 2021/10/23 02:00 | Mazatlan FC v Queretaro | L | 2-1 |
| Mexico Liga MX | 2021/10/19 22:00 | Queretaro v Monterrey | W | 1-0 |
| Mexico Liga MX | 2021/10/15 01:00 | Queretaro v Tijuana | D | 1-1 |
| Mexico Liga MX | 2021/10/09 00:00 | Juarez FC v Queretaro | D | 0-0 |
| Mexico Liga MX | 2021/10/03 17:00 | Toluca v Queretaro | D | 1-1 |
| Mexico Liga MX | 2021/09/30 02:15 | Queretaro v Chivas Guadalajara | W | 1-0 |
| Mexico Liga MX | 2021/09/20 00:00 | Cruz Azul v Queretaro | L | 2-0 |
| Mexico Liga MX | 2021/09/13 00:00 | Queretaro v Necaxa | W | 3-0 |
Away History
| Mexico Liga MX | 2021/10/25 00:06 | Santos Laguna v Toluca | D | 2-2 |
| Mexico Liga MX | 2021/10/20 00:05 | Club America v Santos Laguna | L | 2-1 |
| Mexico Liga MX | 2021/10/17 00:00 | Pachuca v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2021/10/03 00:06 | Santos Laguna v Mazatlan FC | W | 1-0 |
| Mexico Liga MX | 2021/09/27 00:06 | Santos Laguna v Monterrey | L | 1-2 |
| Mexico Liga MX | 2021/09/20 02:06 | Santos Laguna v Puebla | D | 1-1 |
| Leagues Cup | 2021/09/15 02:00 | Seattle Sounders v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2021/09/11 02:06 | Tijuana v Santos Laguna | L | 2-1 |