[3] Benfica 2-1 Santa Clara [10] 2022-02-12 18:00
Stadium: Estadio do Sport Lisboa e Benfica Round: 22
Referee: Helder Miguel Azevedo Malheiro Home Manager: Nelson Verissimo Away Manager: Mario Silva
Head to Head
| Portugal Primeira Liga | 2021/09/11 17:00 | Santa Clara v Benfica | W | 0-5 |
| Portugal Primeira Liga | 2021/04/26 18:00 | Benfica v Santa Clara | W | 2-1 |
| Portugal Primeira Liga | 2021/01/04 17:00 | Santa Clara v Benfica | D | 1-1 |
| Portugal Primeira Liga | 2020/06/23 18:15 | Benfica v Santa Clara | L | 3-4 |
| Portugal Primeira Liga | 2019/11/09 18:00 | Santa Clara v Benfica | W | 1-2 |
| Portugal Primeira Liga | 2019/05/18 17:30 | Benfica v Santa Clara | W | 4-1 |
| Portugal Primeira Liga | 2019/01/11 19:00 | Santa Clara v Benfica | W | 0-2 |
Home History
| Portugal Primeira Liga | 2022/02/07 19:00 | Tondela v Benfica | W | 1-3 |
| Portugal Primeira Liga | 2022/02/02 19:00 | Benfica v Gil Vicente | L | 1-2 |
| Portugal League Cup | 2022/01/29 19:45 | Benfica v Sporting | L | 1-2 |
| Portugal League Cup | 2022/01/25 19:45 | Benfica v Boavista | D | 1-1 |
| Portugal Primeira Liga | 2022/01/21 19:00 | Arouca v Benfica | W | 0-2 |
| Portugal Primeira Liga | 2022/01/15 18:00 | Benfica v Moreirense | D | 1-1 |
| Portugal Primeira Liga | 2022/01/09 18:00 | Benfica v Pacos Ferreira | W | 2-0 |
| Portugal Primeira Liga | 2021/12/30 21:00 | FC Porto v Benfica | L | 3-1 |
Away History
| Portugal Primeira Liga | 2022/02/06 15:30 | Gil Vicente v Santa Clara | D | 2-2 |
| Portugal Primeira Liga | 2022/02/01 20:15 | Santa Clara v Boavista | W | 2-1 |
| Portugal League Cup | 2022/01/26 19:45 | Sporting v Santa Clara | L | 2-1 |
| Portugal Primeira Liga | 2022/01/22 15:30 | Moreirense v Santa Clara | W | 0-2 |
| Portugal Primeira Liga | 2022/01/16 15:30 | Santa Clara v Tondela | D | 2-2 |
| Portugal Primeira Liga | 2022/01/07 18:30 | Santa Clara v Sporting | W | 3-2 |
| Portugal Primeira Liga | 2021/12/30 17:00 | Pacos Ferreira v Santa Clara | L | 2-1 |
| Portugal Primeira Liga | 2021/12/17 19:00 | Santa Clara v Guimaraes | W | 1-0 |