[3] Benfica 2-1 Santa Clara [10] 2022-02-12 18:00
Stadium: Estadio do Sport Lisboa e Benfica Round: 22
Referee: Helder Miguel Azevedo Malheiro Home Manager: Nelson Verissimo Away Manager: Mario Silva
Head to Head
| Portugal Primeira Liga | 2021/09/11 17:00 | Santa Clara v Benfica | W | 0-5 |
| Portugal Primeira Liga | 2021/04/26 18:00 | Benfica v Santa Clara | W | 2-1 |
| Portugal Primeira Liga | 2021/01/04 17:00 | Santa Clara v Benfica | D | 1-1 |
| Portugal Primeira Liga | 2020/06/23 18:15 | Benfica v Santa Clara | L | 3-4 |
| Portugal Primeira Liga | 2019/11/09 18:00 | Santa Clara v Benfica | W | 1-2 |
| Portugal Primeira Liga | 2019/05/18 17:30 | Benfica v Santa Clara | W | 4-1 |
| Portugal Primeira Liga | 2019/01/11 19:00 | Santa Clara v Benfica | W | 0-2 |