[3] Mainz II 2-0 FC Giessen [17] 2021-12-05 13:00
Stadium: Stadion am Bruchweg Round: 21
Referee: Sascha Kief Home Manager: Bartosch Gaul Away Manager: Daniyel Cimen
Head to Head
| Germany Regionalliga South West | 2021/08/21 12:00 | FC Giessen v Mainz II | W | 0-1 |
| Germany Regionalliga South West | 2021/03/20 13:00 | FC Giessen v Mainz II | D | 1-1 |
| Germany Regionalliga South West | 2021/01/12 18:00 | Mainz II v FC Giessen | W | 2-1 |
| Germany Regionalliga South West | 2019/09/15 12:00 | Mainz II v FC Giessen | L | 1-3 |
Home History
| Germany Regionalliga South West | 2021/11/27 13:00 | VfR Aalen v Mainz II | L | 4-3 |
| Germany Regionalliga South West | 2021/11/20 13:00 | TSG Balingen v Mainz II | W | 0-1 |
| Germany Regionalliga South West | 2021/11/13 13:00 | Mainz II v Bahlinger SC | W | 3-0 |
| Germany Regionalliga South West | 2021/11/06 13:00 | Pirmasens v Mainz II | D | 1-1 |
| Germany Regionalliga South West | 2021/10/30 12:00 | Mainz II v TSV Schott Mainz | W | 1-0 |
| Germany Regionalliga South West | 2021/10/23 12:00 | FC Astoria Walldorf v Mainz II | W | 0-2 |
| Germany Regionalliga South West | 2021/10/16 12:00 | Mainz II v Hessen Kassel | L | 1-3 |
| Germany Regionalliga South West | 2021/10/08 15:00 | TSG 1899 Hoffenheim II v Mainz II | W | 0-1 |
Away History
| Germany Regionalliga South West | 2021/11/27 13:00 | FC Giessen v FC Astoria Walldorf | D | 1-1 |
| Germany Regionalliga South West | 2021/11/20 13:00 | FC Giessen v Hessen Kassel | W | 1-0 |
| Germany Regionalliga South West | 2021/11/13 13:00 | TSG 1899 Hoffenheim II v FC Giessen | W | 1-2 |
| Germany Regionalliga South West | 2021/11/06 13:00 | FC Giessen v Rot-Weiss Koblenz | L | 1-2 |
| Germany Regionalliga South West | 2021/10/30 12:00 | SSV Ulm 1846 v FC Giessen | L | 1-0 |
| Germany Regionalliga South West | 2021/10/26 14:00 | FC Giessen v Kickers Offenbach | L | 0-3 |
| Germany Regionalliga South West | 2021/10/23 12:00 | Elversberg v FC Giessen | D | 1-1 |
| Germany Regionalliga South West | 2021/10/16 12:00 | FC Giessen v FC 08 Homburg | L | 0-2 |