[3] Mainz II 2-0 FC Giessen [17] 2021-12-05 13:00
Stadium: Stadion am Bruchweg Round: 21
Referee: Sascha Kief Home Manager: Bartosch Gaul Away Manager: Daniyel Cimen
Head to Head
| Germany Regionalliga South West | 2021/08/21 12:00 | FC Giessen v Mainz II | W | 0-1 |
| Germany Regionalliga South West | 2021/03/20 13:00 | FC Giessen v Mainz II | D | 1-1 |
| Germany Regionalliga South West | 2021/01/12 18:00 | Mainz II v FC Giessen | W | 2-1 |
| Germany Regionalliga South West | 2019/09/15 12:00 | Mainz II v FC Giessen | L | 1-3 |