[5] Man City 0-0 Southampton [14] 2021-09-18 14:00
Stadium: Etihad Stadium Round: 5
Referee: Jonathan Moss Home Manager: Pep Guardiola Away Manager: Ralph Hasenhuttl
Head to Head
| England Premier League | 2021/03/10 18:00 | Man City v Southampton | W | 5-2 |
| England Premier League | 2020/12/19 15:00 | Southampton v Man City | W | 0-1 |
| England Premier League | 2020/07/05 18:00 | Southampton v Man City | L | 1-0 |
| England Premier League | 2019/11/02 15:00 | Man City v Southampton | W | 2-1 |
| England EFL Cup | 2019/10/29 19:45 | Man City v Southampton | W | 3-1 |
| England Premier League | 2018/12/30 14:15 | Southampton v Man City | W | 1-3 |
| England Premier League | 2018/11/04 15:00 | Man City v Southampton | W | 6-1 |
| England Premier League | 2018/05/13 14:00 | Southampton v Man City | W | 0-1 |
Home History
| UEFA Champions League | 2021/09/15 19:00 | Man City v RB Leipzig | W | 6-3 |
| England Premier League | 2021/09/11 14:00 | Leicester v Man City | W | 0-1 |
| England Premier League | 2021/08/28 11:30 | Man City v Arsenal | W | 5-0 |
| England Premier League | 2021/08/21 14:00 | Man City v Norwich | W | 5-0 |
| England Premier League | 2021/08/15 15:30 | Tottenham v Man City | L | 1-0 |
| England Community Shield | 2021/08/07 16:15 | Leicester v Man City | L | 1-0 |
| World Club Friendlies | 2021/08/03 17:00 | Man City v Blackpool | W | 4-1 |
| World Club Friendlies | 2021/07/31 17:00 | Man City v Barnsley | W | 4-0 |
Away History
| England Premier League | 2021/09/11 14:00 | Southampton v West Ham | D | 0-0 |
| England Premier League | 2021/08/28 14:00 | Newcastle v Southampton | D | 2-2 |
| England EFL Cup | 2021/08/25 18:45 | Newport County v Southampton | W | 0-8 |
| England Premier League | 2021/08/22 13:00 | Southampton v Man Utd | D | 1-1 |
| England Premier League | 2021/08/14 14:00 | Everton v Southampton | L | 3-1 |
| Elite Club Friendlies | 2021/08/07 14:00 | Southampton v Athletic Bilbao | L | 1-3 |
| Elite Club Friendlies | 2021/08/04 18:00 | Southampton v Levante | W | 1-0 |
| Elite Club Friendlies | 2021/07/31 14:00 | Swansea v Southampton | W | 1-3 |