[5] Man City 0-0 Southampton [14] 2021-09-18 14:00
Stadium: Etihad Stadium Round: 5
Referee: Jonathan Moss Home Manager: Pep Guardiola Away Manager: Ralph Hasenhuttl
Head to Head
| England Premier League | 2021/03/10 18:00 | Man City v Southampton | W | 5-2 |
| England Premier League | 2020/12/19 15:00 | Southampton v Man City | W | 0-1 |
| England Premier League | 2020/07/05 18:00 | Southampton v Man City | L | 1-0 |
| England Premier League | 2019/11/02 15:00 | Man City v Southampton | W | 2-1 |
| England EFL Cup | 2019/10/29 19:45 | Man City v Southampton | W | 3-1 |
| England Premier League | 2018/12/30 14:15 | Southampton v Man City | W | 1-3 |
| England Premier League | 2018/11/04 15:00 | Man City v Southampton | W | 6-1 |
| England Premier League | 2018/05/13 14:00 | Southampton v Man City | W | 0-1 |
| England Premier League | 2017/11/29 20:00 | Man City v Southampton | W | 2-1 |
| England Premier League | 2017/04/15 16:30 | Southampton v Man City | W | 0-3 |
| England Premier League | 2016/10/23 12:30 | Man City v Southampton | D | 1-1 |
| England Premier League | 2016/05/01 15:30 | Southampton v Man City | L | 4-2 |
| England Premier League | 2015/11/28 15:00 | Man City v Southampton | W | 3-1 |
| England Premier League | 2015/05/24 14:00 | Man City v Southampton | W | 2-0 |
| England Premier League | 2014/11/30 13:30 | Southampton v Man City | W | 0-3 |