[7] Arsenal 3-0 Southampton [16] 2021-12-11 15:00
Stadium: Emirates Stadium Round: 16
Referee: Jarred Gillett Home Manager: Mikel Arteta Away Manager: Ralph Hasenhuttl
Head to Head
| England Premier League | 2021/01/26 20:15 | Southampton v Arsenal | W | 1-3 |
| England FA Cup | 2021/01/23 12:15 | Southampton v Arsenal | L | 1-0 |
| England Premier League | 2020/12/16 18:00 | Arsenal v Southampton | D | 1-1 |
| England Premier League | 2020/06/25 17:00 | Southampton v Arsenal | W | 0-2 |
| England Premier League | 2019/11/23 15:00 | Arsenal v Southampton | D | 2-2 |
| England Premier League | 2019/02/24 14:05 | Arsenal v Southampton | W | 2-0 |
| England Premier League | 2018/12/16 13:30 | Southampton v Arsenal | L | 3-2 |
| England Premier League | 2018/04/08 13:15 | Arsenal v Southampton | W | 3-2 |
Home History
| England Premier League | 2021/12/06 20:00 | Everton v Arsenal | L | 2-1 |
| England Premier League | 2021/12/02 20:15 | Man Utd v Arsenal | L | 3-2 |
| England Premier League | 2021/11/27 12:30 | Arsenal v Newcastle | W | 2-0 |
| England Premier League | 2021/11/20 17:30 | Liverpool v Arsenal | L | 4-0 |
| England Premier League | 2021/11/07 14:00 | Arsenal v Watford | W | 1-0 |
| England Premier League | 2021/10/30 11:30 | Leicester v Arsenal | W | 0-2 |
| England EFL Cup | 2021/10/26 18:45 | Arsenal v Leeds | W | 2-0 |
| England Premier League | 2021/10/22 19:00 | Arsenal v Aston Villa | W | 3-1 |
Away History
| England Premier League | 2021/12/04 15:00 | Southampton v Brighton | D | 1-1 |
| England Premier League | 2021/12/01 19:30 | Southampton v Leicester | D | 2-2 |
| England Premier League | 2021/11/27 15:00 | Liverpool v Southampton | L | 4-0 |
| England Premier League | 2021/11/20 15:00 | Norwich v Southampton | L | 2-1 |
| England Premier League | 2021/11/05 20:00 | Southampton v Aston Villa | W | 1-0 |
| England Premier League | 2021/10/30 14:00 | Watford v Southampton | W | 0-1 |
| England EFL Cup | 2021/10/26 18:45 | Chelsea v Southampton | L | 5-4 |
| England Premier League | 2021/10/23 14:00 | Southampton v Burnley | D | 2-2 |