[7] Arsenal 3-0 Southampton [16] 2021-12-11 15:00
Stadium: Emirates Stadium Round: 16
Referee: Jarred Gillett Home Manager: Mikel Arteta Away Manager: Ralph Hasenhuttl
Head to Head
| England Premier League | 2021/01/26 20:15 | Southampton v Arsenal | W | 1-3 |
| England FA Cup | 2021/01/23 12:15 | Southampton v Arsenal | L | 1-0 |
| England Premier League | 2020/12/16 18:00 | Arsenal v Southampton | D | 1-1 |
| England Premier League | 2020/06/25 17:00 | Southampton v Arsenal | W | 0-2 |
| England Premier League | 2019/11/23 15:00 | Arsenal v Southampton | D | 2-2 |
| England Premier League | 2019/02/24 14:05 | Arsenal v Southampton | W | 2-0 |
| England Premier League | 2018/12/16 13:30 | Southampton v Arsenal | L | 3-2 |
| England Premier League | 2018/04/08 13:15 | Arsenal v Southampton | W | 3-2 |
| England Premier League | 2017/12/10 12:00 | Southampton v Arsenal | D | 1-1 |
| England Premier League | 2017/05/10 18:45 | Southampton v Arsenal | W | 0-2 |
| England FA Cup | 2017/01/28 17:30 | Southampton v Arsenal | W | 0-5 |
| England EFL Cup | 2016/11/30 19:45 | Arsenal v Southampton | L | 0-2 |
| England Premier League | 2016/09/10 14:00 | Arsenal v Southampton | W | 2-1 |
| England Premier League | 2016/02/02 19:45 | Arsenal v Southampton | D | 0-0 |
| England Premier League | 2015/12/26 19:45 | Southampton v Arsenal | L | 4-0 |
| England Premier League | 2015/01/01 15:00 | Southampton v Arsenal | L | 2-0 |
| England Premier League | 2014/12/03 19:45 | Arsenal v Southampton | W | 1-0 |
| England EFL Cup | 2014/09/23 18:45 | Arsenal v Southampton | L | 1-2 |