[14] Southampton 1-1 Tottenham [5] 2021-12-28 15:00
Stadium: St. Mary's Stadium Round: 20
Referee: Anthony Taylor Home Manager: Ralph Hasenhuttl Away Manager: Antonio Conte
Head to Head
| England Premier League | 2021/04/21 17:00 | Tottenham v Southampton | L | 2-1 |
| England Premier League | 2020/09/20 11:00 | Southampton v Tottenham | L | 2-5 |
| England FA Cup | 2020/02/05 19:45 | Tottenham v Southampton | L | 3-2 |
| England FA Cup | 2020/01/25 15:00 | Southampton v Tottenham | D | 1-1 |
| England Premier League | 2020/01/01 15:00 | Southampton v Tottenham | W | 1-0 |
| England Premier League | 2019/09/28 14:00 | Tottenham v Southampton | L | 2-1 |
| England Premier League | 2019/03/09 15:00 | Southampton v Tottenham | W | 2-1 |
| England Premier League | 2018/12/05 20:00 | Tottenham v Southampton | L | 3-1 |
Home History
| England Premier League | 2021/12/26 15:00 | West Ham v Southampton | W | 2-3 |
| England Premier League | 2021/12/15 19:30 | Crystal Palace v Southampton | D | 2-2 |
| England Premier League | 2021/12/11 15:00 | Arsenal v Southampton | L | 3-0 |
| England Premier League | 2021/12/04 15:00 | Southampton v Brighton | D | 1-1 |
| England Premier League | 2021/12/01 19:30 | Southampton v Leicester | D | 2-2 |
| England Premier League | 2021/11/27 15:00 | Liverpool v Southampton | L | 4-0 |
| England Premier League | 2021/11/20 15:00 | Norwich v Southampton | L | 2-1 |
| England Premier League | 2021/11/05 20:00 | Southampton v Aston Villa | W | 1-0 |
Away History
| England Premier League | 2021/12/26 15:00 | Tottenham v Crystal Palace | W | 3-0 |
| England EFL Cup | 2021/12/22 19:45 | Tottenham v West Ham | W | 2-1 |
| England Premier League | 2021/12/19 16:30 | Tottenham v Liverpool | D | 2-2 |
| England Premier League | 2021/12/05 14:00 | Tottenham v Norwich | W | 3-0 |
| England Premier League | 2021/12/02 19:30 | Tottenham v Brentford | W | 2-0 |
| UEFA Conference League | 2021/11/25 17:45 | NS Mura v Tottenham | L | 2-1 |
| England Premier League | 2021/11/21 16:30 | Tottenham v Leeds | W | 2-1 |
| England Premier League | 2021/11/07 14:00 | Everton v Tottenham | D | 0-0 |