[7] Tottenham 2-3 Southampton [12] 2022-02-09 19:45
Stadium: Tottenham Hotspur Stadium Round: 24
Referee: David Coote Home Manager: Antonio Conte Away Manager: Ralph Hasenhuttl
Head to Head
| England Premier League | 2021/12/28 15:00 | Southampton v Tottenham | D | 1-1 |
| England Premier League | 2021/04/21 17:00 | Tottenham v Southampton | W | 2-1 |
| England Premier League | 2020/09/20 11:00 | Southampton v Tottenham | W | 2-5 |
| England FA Cup | 2020/02/05 19:45 | Tottenham v Southampton | W | 3-2 |
| England FA Cup | 2020/01/25 15:00 | Southampton v Tottenham | D | 1-1 |
| England Premier League | 2020/01/01 15:00 | Southampton v Tottenham | L | 1-0 |
| England Premier League | 2019/09/28 14:00 | Tottenham v Southampton | W | 2-1 |
| England Premier League | 2019/03/09 15:00 | Southampton v Tottenham | L | 2-1 |
Home History
| England FA Cup | 2022/02/05 20:00 | Tottenham v Brighton | W | 3-1 |
| England Premier League | 2022/01/23 16:30 | Chelsea v Tottenham | L | 2-0 |
| England Premier League | 2022/01/19 19:30 | Leicester v Tottenham | W | 2-3 |
| England EFL Cup | 2022/01/12 19:45 | Tottenham v Chelsea | L | 0-1 |
| England FA Cup | 2022/01/09 14:00 | Tottenham v Morecambe | W | 3-1 |
| England EFL Cup | 2022/01/05 19:45 | Chelsea v Tottenham | L | 2-0 |
| England Premier League | 2022/01/01 15:00 | Watford v Tottenham | W | 0-1 |
| England Premier League | 2021/12/28 15:00 | Southampton v Tottenham | D | 1-1 |
Away History
| England FA Cup | 2022/02/05 15:00 | Southampton v Coventry | D | 1-1 |
| England Premier League | 2022/01/22 17:30 | Southampton v Man City | D | 1-1 |
| England Premier League | 2022/01/15 15:00 | Wolverhampton v Southampton | L | 3-1 |
| England Premier League | 2022/01/11 19:45 | Southampton v Brentford | W | 4-1 |
| England FA Cup | 2022/01/08 17:30 | Swansea v Southampton | D | 1-1 |
| England Premier League | 2021/12/28 15:00 | Southampton v Tottenham | D | 1-1 |
| England Premier League | 2021/12/26 15:00 | West Ham v Southampton | W | 2-3 |
| England Premier League | 2021/12/15 19:30 | Crystal Palace v Southampton | D | 2-2 |