[5] Club America Women 2-1 Santos Laguna Women [5] 2021-07-18 17:00
Stadium: Estadio Azteca Round: 1
Head to Head
| Mexico Liga MX Femenil | 2021/04/06 00:00 | Santos Laguna Women v Club America Women | W | 1-2 |
| Mexico Liga MX Femenil | 2020/09/18 21:00 | Club America Women v Santos Laguna Women | W | 2-1 |
| Mexico Liga MX Femenil | 2020/01/20 21:45 | Club America Women v Santos Laguna Women | W | 3-2 |
| Mexico Liga MX Femenil | 2019/10/22 00:00 | Santos Laguna Women v Club America Women | W | 0-1 |
Home History
| Mexico Liga MX Femenil | 2021/05/11 01:00 | Tigres UANL Women v Club America Women | L | 2-0 |
| Mexico Liga MX Femenil | 2021/05/07 15:00 | Club America Women v Tigres UANL Women | L | 0-4 |
| Mexico Liga MX Femenil | 2021/05/02 17:00 | Puebla Women v Club America Women | L | 1-0 |
| Mexico Liga MX Femenil | 2021/04/25 17:00 | Club America Women v Cruz Azul Women | W | 2-1 |
| Mexico Liga MX Femenil | 2021/04/19 22:00 | Monterrey Women v Club America Women | D | 1-1 |
| Mexico Liga MX Femenil | 2021/04/06 00:00 | Santos Laguna Women v Club America Women | W | 1-2 |
| Mexico Liga MX Femenil | 2021/03/28 02:07 | Club America Women v Chivas Guadalajara Women | L | 2-4 |
| Mexico Liga MX Femenil | 2021/03/28 02:05 | Club America Women v Chivas Guadalajara Women | L | 2-4 |
Away History
| Mexico Liga MX Femenil | 2021/05/01 15:00 | Mazatlan FC Women v Santos Laguna Women | W | 2-3 |
| Mexico Liga MX Femenil | 2021/04/27 00:00 | Santos Laguna Women v Juarez FC Women | W | 3-0 |
| Mexico Liga MX Femenil | 2021/04/19 21:00 | Toluca Women v Santos Laguna Women | L | 1-0 |
| Mexico Liga MX Femenil | 2021/04/06 00:00 | Santos Laguna Women v Club America Women | L | 1-2 |
| Mexico Liga MX Femenil | 2021/03/29 22:30 | Santos Laguna Women v Cruz Azul Women | W | 2-1 |
| Mexico Liga MX Femenil | 2021/03/21 23:00 | Atletico San Luis Women v Santos Laguna Women | D | 2-2 |
| Mexico Liga MX Femenil | 2021/03/16 01:00 | Tijuana Women v Santos Laguna Women | W | 0-1 |
| Mexico Liga MX Femenil | 2021/03/11 22:00 | Santos Laguna Women v Unam Pumas Women | D | 2-2 |