[5] Club America Women 2-1 Santos Laguna Women [5] 2021-07-18 17:00
Stadium: Estadio Azteca Round: 1
Head to Head
| Mexico Liga MX Femenil | 2021/04/06 00:00 | Santos Laguna Women v Club America Women | W | 1-2 |
| Mexico Liga MX Femenil | 2020/09/18 21:00 | Club America Women v Santos Laguna Women | W | 2-1 |
| Mexico Liga MX Femenil | 2020/01/20 21:45 | Club America Women v Santos Laguna Women | W | 3-2 |
| Mexico Liga MX Femenil | 2019/10/22 00:00 | Santos Laguna Women v Club America Women | W | 0-1 |