[17] Mazatlan FC Women 0-2 Santos Laguna Women [14] 2021-07-24 01:00
Stadium: Estadio Morelos Round: 2
Head to Head
| Mexico Liga MX Femenil | 2021/05/01 15:00 | Mazatlan FC Women v Santos Laguna Women | L | 2-3 |
| Mexico Liga MX Femenil | 2020/11/06 03:00 | Santos Laguna Women v Mazatlan FC Women | D | 1-1 |
| Mexico Liga MX Femenil | 2020/02/03 22:00 | Mazatlan FC Women v Santos Laguna Women | W | 1-0 |
| Mexico Liga MX Femenil | 2019/11/05 01:00 | Santos Laguna Women v Mazatlan FC Women | W | 1-2 |
| Mexico Liga MX Femenil | 2019/03/03 18:00 | Mazatlan FC Women v Santos Laguna Women | D | 2-2 |
| Mexico Liga MX Femenil | 2019/01/15 03:00 | Santos Laguna Women v Mazatlan FC Women | D | 1-1 |
| Mexico Liga MX Femenil | 2018/09/24 21:00 | Mazatlan FC Women v Santos Laguna Women | W | 3-2 |
| Mexico Liga MX Femenil | 2018/07/24 02:00 | Santos Laguna Women v Mazatlan FC Women | D | 1-1 |
Home History
| Mexico Liga MX Femenil | 2021/07/20 00:00 | Tigres UANL Women v Mazatlan FC Women | L | 2-0 |
| Mexico Liga MX Femenil | 2021/05/01 15:00 | Mazatlan FC Women v Santos Laguna Women | L | 2-3 |
| Mexico Liga MX Femenil | 2021/04/27 00:00 | Tigres UANL Women v Mazatlan FC Women | D | 2-2 |
| Mexico Liga MX Femenil | 2021/04/17 15:00 | Mazatlan FC Women v Pachuca Women | L | 0-2 |
| Mexico Liga MX Femenil | 2021/04/05 21:00 | Toluca Women v Mazatlan FC Women | L | 1-0 |
| Mexico Liga MX Femenil | 2021/03/27 01:00 | Mazatlan FC Women v Unam Pumas Women | D | 0-0 |
| Mexico Liga MX Femenil | 2021/03/18 16:00 | Cruz Azul Women v Mazatlan FC Women | L | 3-0 |
| Mexico Liga MX Femenil | 2021/03/14 16:00 | Mazatlan FC Women v Puebla Women | D | 1-1 |
Away History
| Mexico Liga MX Femenil | 2021/07/18 17:00 | Club America Women v Santos Laguna Women | L | 2-1 |
| Mexico Liga MX Femenil | 2021/05/01 15:00 | Mazatlan FC Women v Santos Laguna Women | W | 2-3 |
| Mexico Liga MX Femenil | 2021/04/27 00:00 | Santos Laguna Women v Juarez FC Women | W | 3-0 |
| Mexico Liga MX Femenil | 2021/04/19 21:00 | Toluca Women v Santos Laguna Women | L | 1-0 |
| Mexico Liga MX Femenil | 2021/04/06 00:00 | Santos Laguna Women v Club America Women | L | 1-2 |
| Mexico Liga MX Femenil | 2021/03/29 22:30 | Santos Laguna Women v Cruz Azul Women | W | 2-1 |
| Mexico Liga MX Femenil | 2021/03/21 23:00 | Atletico San Luis Women v Santos Laguna Women | D | 2-2 |
| Mexico Liga MX Femenil | 2021/03/16 01:00 | Tijuana Women v Santos Laguna Women | W | 0-1 |