[17] Mazatlan FC Women 0-2 Santos Laguna Women [14] 2021-07-24 01:00
Stadium: Estadio Morelos Round: 2
Head to Head
| Mexico Liga MX Femenil | 2021/05/01 15:00 | Mazatlan FC Women v Santos Laguna Women | L | 2-3 |
| Mexico Liga MX Femenil | 2020/11/06 03:00 | Santos Laguna Women v Mazatlan FC Women | D | 1-1 |
| Mexico Liga MX Femenil | 2020/02/03 22:00 | Mazatlan FC Women v Santos Laguna Women | W | 1-0 |
| Mexico Liga MX Femenil | 2019/11/05 01:00 | Santos Laguna Women v Mazatlan FC Women | W | 1-2 |
| Mexico Liga MX Femenil | 2019/03/03 18:00 | Mazatlan FC Women v Santos Laguna Women | D | 2-2 |
| Mexico Liga MX Femenil | 2019/01/15 03:00 | Santos Laguna Women v Mazatlan FC Women | D | 1-1 |
| Mexico Liga MX Femenil | 2018/09/24 21:00 | Mazatlan FC Women v Santos Laguna Women | W | 3-2 |
| Mexico Liga MX Femenil | 2018/07/24 02:00 | Santos Laguna Women v Mazatlan FC Women | D | 1-1 |