[15] Toluca Women 1-0 Santos Laguna Women [4] 2021-10-09 21:00
Stadium: Estadio Nemesio Diez Round: 12
Head to Head
| Mexico Liga MX Femenil | 2021/04/19 21:00 | Toluca Women v Santos Laguna Women | W | 1-0 |
| Mexico Liga MX Femenil | 2020/11/20 01:00 | Santos Laguna Women v Toluca Women | L | 2-0 |
| Mexico Liga MX Femenil | 2019/11/12 01:00 | Toluca Women v Santos Laguna Women | W | 2-0 |
Home History
| Mexico Liga MX Femenil | 2021/10/03 00:00 | Pachuca Women v Toluca Women | D | 1-1 |
| Mexico Liga MX Femenil | 2021/09/28 00:00 | Toluca Women v Puebla Women | D | 1-1 |
| Mexico Liga MX Femenil | 2021/09/11 17:00 | Cruz Azul Women v Toluca Women | L | 2-1 |
| Mexico Liga MX Femenil | 2021/09/06 22:00 | Toluca Women v Club Necaxa Women | L | 0-1 |
| Mexico Liga MX Femenil | 2021/08/31 00:00 | Tigres UANL Women v Toluca Women | L | 4-0 |
| Mexico Liga MX Femenil | 2021/08/24 00:00 | Monterrey Women v Toluca Women | L | 2-0 |
| Mexico Liga MX Femenil | 2021/08/14 17:00 | Toluca Women v Juarez FC Women | D | 1-1 |
| Mexico Liga MX Femenil | 2021/08/10 00:00 | Club America Women v Toluca Women | W | 1-3 |
Away History
| Mexico Liga MX Femenil | 2021/10/05 02:00 | Juarez FC Women v Santos Laguna Women | W | 1-2 |
| Mexico Liga MX Femenil | 2021/09/27 22:00 | Santos Laguna Women v Monterrey Women | D | 2-2 |
| Mexico Liga MX Femenil | 2021/09/13 02:00 | Santos Laguna Women v Chivas Guadalajara Women | W | 5-4 |
| Mexico Liga MX Femenil | 2021/09/05 17:00 | Puebla Women v Santos Laguna Women | W | 2-3 |
| Mexico Liga MX Femenil | 2021/08/31 02:00 | Santos Laguna Women v Cruz Azul Women | W | 4-0 |
| Mexico Liga MX Femenil | 2021/08/24 00:00 | Leon Women v Santos Laguna Women | W | 1-6 |
| Mexico Liga MX Femenil | 2021/08/17 02:00 | Santos Laguna Women v Atlas Women | D | 2-2 |
| Mexico Liga MX Femenil | 2021/08/09 22:00 | Club Necaxa Women v Santos Laguna Women | W | 0-3 |